Friday, February 3, 2023

Medication To Treat Lyme Disease

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Which Children Are At Risk For Lyme Disease

Doxycycline and Lyme Disease Treatment

A child is more at risk for Lyme disease in certain parts of the U.S. during the spring and summer months, when ticks are more active. Ticks live in wooded areas, low-growing grasslands, and yards. A child is more at risk outdoors in these places, or around a pet that has been in these areas.

Lyme has been reported in nearly all states. The most cases have been reported in:

  • Northeastern states, such as Massachusetts and Connecticut
  • Mid-Atlantic states, such as New Jersey and Pennsylvania
  • Wisconsin and Minnesota

Many cases have also been reported in Asia and Europe.

Iv Antibiotic Regimen: Cephalosporin Plus Azole Plus Liposomal Cinnamon Clove And Oregano

  • ceftriaxone 2 gm IV 2 times a day for 4 days on and 3 days off
  • tinidazole 500 mg taken orally 1 pill 2-3 times a day for 4 days on and 3 days off in 7-day cycles
  • liposomal cinnamon, clove, and oregano capsules 1 pill 2 times a day

Key Points:

  • Various antibiotics can be used as IV. I use this one most commonly because it is the easiest to administer and one of the lowest cost IV regimens. The ceftriaxone is given in a syringe and injected over 10 minutes. This is also a pulse dose regimen . Ceftriaxone could be given daily instead as 2 gm IV 1 time a day.
  • I have found various pulse dose regimens of tinidazole to work. These include 2 weeks on and 2 weeks off or in the regimen seen here.

Azlocillin An Amazing Compound

The study team first tested to see whether different doses of the drugs could kill drug-tolerant borrelia bacteria grown on laboratory plates better than a standard Lyme disease antibiotic .

They carried out each experiment three times in triplicate . The team tested the drugs on different ages of bacteria, colonies that were 3 days old and growing rapidly, and colonies that were 710 days old and had reached a growth plateau.

At high concentrations, both drugs could kill all the drug-resistant borrelia cells and outperformed the standard Lyme disease antibiotic. When the study team tested the drugs at lower doses, azlocillin outperformed the standard antibiotic and cefotaxime, which left 20% of the drug-resistant cells alive.

The researchers tested the drugs in a small number of laboratory-bred mice that they infected with the bacteria. They treated the mice at different stages of the disease at 7, 14, and 21 days after infection.

They gave each mouse a daily dose of either azlocillin, cefotaxime, or the standard treatment for Lyme disease for 5 days. They cultured the mouse organs and checked for live bacteria using microscopy and genetic testing 2 days after the last dose.

The researchers found that both the standard treatment and azlocillin completely cleared the infection in the early stages of the disease, while cefotaxime did not.

We have been screening potential drugs for 6 years, Venkata Raveendra Pothineni, Ph.D., the lead study author says.

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Lyme Disease Treatment Market To Register High Revenue Growth During 2021

Lyme disease treatment market is projected to reach US$ 3 Bn by 2031

The Global Lyme Disease Treatment Market is estimated to attain a valuation of US$ 3 Bn by the end of 2031, states a study by Transparency Market Research . Besides, the report notes that the market is prognosticated to expand at a CAGR of 6% during the forecast period, 2021 to 2031.

The key objective of the TMR report is to offer a complete assessment of the global market including major leading stakeholders of the Lyme Disease Treatment industry. The current and historical status of the market together with forecasted market size and trends are demonstrated in the assessment in simple manner. In addition, the report delivers data on the volume, share, revenue, production, and sales in the market.

The report by TMR is the end-product of a study performed using different methodologies including the PESTEL, PORTER, and SWOT analysis. The study with the help of these models shed light on the key financial considerations that players in the Lyme Disease Treatment Market need to focus on identifying competition and formulate their marketing strategies for both consumer and industrial markets. The report leverages a wide spectrum of research methods including surveys, interviews, and social media listening to analyze consumer behaviors in its entirety.

Lyme Disease Treatment Market: Industry Trends and Value Chain

Late Or Chronic Lyme Disease Treatment

3 Month Lyme Disease Treatment Plan

Experts agree that the earlier you are treated the better, since early treatment is often successful. Unfortunately, a substantial portion of patients treated with short-term antibiotics continue to have significant symptoms. The quality of life of patients with chronic Lyme disease is similar to that of patients with congestive heart failure. Doctors dont agree about the cause of these ongoing symptoms. The primary cause of this debate is flawed diagnostic testing. There is currently no test that can determine whether a patient has active infection or whether the infection has been eradicated by treatment.

The IDSA thinks Lyme disease symptoms after treatment represent a possibly autoimmune, post-Lyme syndrome that is not responsive to antibiotics. The IDSA essentially regards Lyme disease as an acute infection like strep throat that can be treated with a short course of antibiotics. The IDSA guidelines are now eight years old and do not reflect recent science.

ILADS physicians believe that ongoing symptoms probably reflect active infection, which should be treated until the symptoms have resolved. These physicians use treatment approaches employed for persistent infections like tuberculosis, including a combination of drugs and longer treatment durations. The ILADS guidelines have just recently been updated using a rigorous review of the medical literature.

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How Do Humans Get Lyme Disease

The germ that causes Lyme disease lives in certain animals. These are mainly rodents such as mice, some birds and some other small animals. The bacterium is usually harmless to the animals.

Ticks are small insect-like creatures, about the size of a pinhead. Ticks feed by biting the skin and sucking blood from animals such as mice, and sometimes humans. In this way, some ticks become infected with the bacterium that causes Lyme disease.

Ticks cannot jump or fly but climb on to passing humans from long grass or foliage. If an infected tick bites a human then the bacteria may be passed into the human. The bacterium that causes Lyme disease is not passed from person to person. Note: most ticks in the UK are not infected by the bacterium that causes Lyme disease. Therefore, most tick bites will not cause Lyme disease.

After a person has been bitten by a tick, it usually takes 24-48 hours for the bacteria in the tick to pass into that person. with blood. The bacteria are normally carried in their gut and only travel up to their mouth and into your skin once they have been fed and are engorged. This normally takes about 24 hours but can be less if the tick was already partially fed.) Therefore, if you remove a tick soon after being bitten within 24 hours you are much less likely to develop Lyme disease, even if it was an infected tick.

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Symptoms Of Early Stage Lyme Disease

According to the Centers for Disease Control and Prevention , early-stage Lyme disease symptoms crop up within 3 to 30 days after exposure and can include but are not limited to:

  • Swelling of the lymph nodes
  • Erythema migrans , a bulls-eye-shaped rash that appears at the site of the tick bite

Early Lyme disease does not always appear the same in all patients. For example, up to 30% of patients dont remember experiencing a bulls eye rash.

Also Check: Lyme Disease Test Turnaround Time

Penicillin Plus Azole Plus Lipsomal Cinnamon Clove & Oregano Oil

  • amoxicillin 500 mg 4 pills 3 times a day
  • tinidazole 500 mg 1 pill 2 or 3 times a day for 4 days on and 3 days off in 7-day cycles.
  • liposomal cinnamon, clove, and oregano oil capsules 1 pill 2 times a day.

Key Points:

  • This is a very high dose of amoxicillin, which is four times stronger than physicians prescribe for other infections like ear infections. I consider this dose to be nearly as effective as IV antibiotics.
  • This is a pulse dose regimen of the tinidazole. It may be more effective than continuous regimens.
  • The essential oils are added to treat persister Lyme.

Lyme Disease Treatment Is Different For Everyone

Alternative treatments for Lyme disease symptoms brings new hope to those suffering

PTLDS symptoms vary widely so no single treatment works for everyone. Thats why self-reporting is so effective. Its a systematic way to learn about your specific symptoms, allowing you to tailor the right PTLDS treatment so you can start feeling good again.

Regularly documenting your symptoms gives you accurate, timely information that informs how you manage your PTLDS. But doing this alone, can be confusing and overwhelming. Because of this, working with a health professional who provides support and information is recommended.

When you work with a Mymee health coach, you’ll receive a personalized plan specific to your PTLDS symptoms. They also help you set expectations and prepare you for long-term success.

Start on a path to better health. Schedule a session with a Mymee health coach to learn how to effectively start treating your PTLDS symptoms today.

Read Also: How To Recover From Lyme Disease

What Are Possible Complications Of Lyme Disease In A Child

Some children may develop post-Lyme disease syndrome . This means that some symptoms last longer than 6 months. Symptoms can include:

  • Ongoing muscle and nerve pain
  • Problems with memory

PLDS does not respond to antibiotics. That’s because there isn’t an active infection anymore. Treatment is aimed at helping to control the symptoms.

Why Are Antibiotics The First Line Of Treatment For Lyme Disease

The use of antibiotics is critical for treating Lyme disease. Without antibiotic treatment, the Lyme disease causing bacteria can evade the host immune system, disseminate through the blood stream, and persist in the body. Antibiotics go into the bacteria preferentially and either stop the multiplication of the bacteria or disrupt the cell wall of the bacteria and kill the bacteria . By stopping the growth or killing the bacteria the human host immune response is given a leg up to eradicate the residual infection. Without antibiotics, the infection in Lyme disease can evade the host immune system and more readily persist.

Read Also: How To Treat Dogs For Lyme Disease

Can Lyme Disease Be Prevented

Most people with Lyme disease get the infection during the late spring, summer and early fall when immature ticks are out feeding. In warm climates, few tick bites take place during winter months.

Deer ticks are most often found in wooded areas and nearby grasslands. Theyre especially common where the two areas merge, including neighborhood yards where deer occasionally roam. Ticks dont survive long on sunny lawns. They dry out quickly and die.

Although only about 1% of all deer ticks carry Lyme disease-causing bacteria, there are areas in which over 50% of the ticks carry the bacterium. The diseased ticks are often found in the U.S. Northeast and upper Midwest areas. Ticks also live in coastal areas.

Black-legged ticks can get the infection from animals other than deer. Mice, voles and some squirrels can carry the bacteria.

How can I prevent tick bites?

The following tips can help you avoid tick bites:

What Are The Side Effects Of Lyme Disease Treatments

Supplements For Lyme Disease Treatment

Antibiotics, like all medications, have the potential for side effects. Any antibiotic can cause skin rashes, and if an itchy red rash develops while on antibiotics, a patient should see their physician. Sometimes symptoms worsen for the first few days on an antibiotic. This is called a Herxheimer reaction and occurs when the antibiotics start to kill the bacteria. In the first 24 to 48 hours, dead bacterial products stimulate the immune system to release inflammatory cytokines and chemokines that can cause increased fever and achiness. This should be transient and last no more than a day or two after the initiation of antibiotics.

The most common side effect of the penicillin antibiotics is diarrhea, and occasionally even serious cases caused by the bacteria Clostridium difficile. This bacterial overgrowth condition occurs because antibiotics kill the good bacteria in our gut. It can be helpful to use probiotics to restore the good bacteria and microbiome balance.

Recommended Reading: How To Get Diagnosed With Lyme Disease

Herbal And Prescription Antimicrobials By Function

Be aware the doses I provide below are for adults. These same prescriptions can be used with children but have lower doses. For pediatric dosing, talk with your family physician or pediatrician. Tetracyclines can be used in children under eight, but there is a risk of tooth staining. This staining seems not to be an issue if they are used for a month or less.

Has Niaid Looked At The Potential Benefits Of Long

Yes. NIAID has funded three placebo-controlled clinical trials on the efficacy of prolonged antibiotic therapy for treating PTLDS. The published results were subjected to rigorous statistical, editorial, and scientific peer review.

These trials were designed to ensure that several key parameters were addressed:

  • The susceptibility of B.burgdorferi to the antibiotics used
  • The ability of the antibiotics to both cross the blood-brain barrier and access the central nervous system and to persist at effective levels throughout the course of therapy
  • The ability of the antibiotics to kill bacteria living both outside and inside mammalian cells
  • The safety and welfare of patients enrolled in the trials

The first clinical trial, which included two multicenter studies, provided no evidence that extended antibiotic treatment is beneficial. In those studies, physicians examined long-term antibiotic therapy in patients with a well-documented history of previous Lyme disease but who reported persistent pain, fatigue, impaired cognitive function, or unexplained numbness. Those symptoms are common among people reporting PTLDS. Patients were treated with 30 days of an intravenous antibiotic followed by 60 days of an oral antibiotic.

In 2016, a clinical trial conducted in the Netherlands also concluded that in patients with persistent symptoms attributed to Lyme disease, longer term treatment with antibiotics did not provide additional benefits compared with shorter term regimens.

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What Is Chronic Lyme Disease

Lyme disease is an infection caused by the bacterium Borrelia burgdorferi. In the majority of cases, it is successfully treated with oral antibiotics. In some patients, symptoms, such as fatigue, pain and joint and muscle aches, persist even after treatment, a condition termed Post Treatment Lyme Disease Syndrome .

The term chronic Lyme disease has been used to describe people with different illnesses. While the term is sometimes used to describe illness in patients with Lyme disease, it has also been used to describe symptoms in people who have no clinical or diagnostic evidence of a current or past infection with B. burgdorferi . Because of the confusion in how the term CLD is employed, and the lack of a clearly defined clinical definition, many experts in this field do not support its use.

Quinine Derivatives To Boost Intracellular Antibiotics

Lyme Disease Treatment – Johns Hopkins (4 of 5)

Intracellular

Inside of cells, Lyme may live in cave-like structures called vacuoles. In these vacuoles, Lyme germs create a hostile acidic environment that can limit the effectiveness of various antibiotics. Quinine derivatives, like hydroxychloroquine , can make the inside of cells more basic which can help the tetracyclines and macrolides mentioned above work better.

  • Hydroxychloroquine 200 mg 1 pill 2 times a day

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How Is Lyme Disease Treated

Antibiotics, usually doxycycline or amoxicillin, are effective treatments for Lyme disease. How long your treatment lasts depends on the stage of infection. In general, its true that the sooner youre treated, the quicker and more complete the recovery.

Pregnant people should receive treatment for Lyme disease as well. There is, however, no evidence that a fetus can get the infection from its parent. Theres also no strong evidence that miscarriages are more likely after Lyme disease.

What should I do if a tick bites me?

If a tick bites you, the best way to remove it is by taking the following steps:

  • Tug gently but firmly with blunt tweezers near the “head” of the tick at the level of your skin until it releases its hold on your skin.
  • Avoid crushing the tick’s body or handling the tick with bare fingers because you could expose yourself to the bacteria in the tick.
  • Wash the bite area thoroughly with soap and water.
  • Don’t use kerosene, petroleum jelly or hot cigarette butts to remove the tick.
  • Don’t squeeze the tick’s body with your fingers or tweezers.

Common Misconceptions About Lyme Disease:

1. If a dog tests positive for Lyme disease, it means she has it.

2. Dogs are much more likely than people to become ill from Lyme disease.

3. A dog infected with Lyme disease will tend to start showing symptoms within a month, and sometimes within the first 18 hours.

4. Dogs can transmit Lyme disease to people.

5. Lyme disease strikes only in warm weather.

A lot of times, a dog will test positive for Lyme disease, and her owners get nervous that their pet is sick and needs treatment, but the dog is fine. How can that be?

Its because testing positive for Lyme simply means that antibodies to the illness have been detected in the dogs blood. It does not mean that the animals body is actually being affected by the disease. How can that be?

The fact that a dog can test positive for Lyme disease yet not actually have it in a way that matters has led to a lot of nervous owners, and sometimes, even veterinarians who have over-treated. To clear up the misconceptions, heres what you need to know.

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