Friday, July 19, 2024

Symptoms Of Lyme Disease After Treatment

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What Is Late Lyme Disease

Understanding the Persistent Symptoms in Lyme Disease | Johns Hopkins Medicine

Lyme disease, also known as Lyme borreliosis, is caused by an infection with the bacteria Borrelia burgdorferi. This bacteria is disseminated through tick bites. Infected ticks usually bite small mammals, who do not develop any kind of infection from the bacteria. When humans are exposed to B. Burgdorferi from a tick bite, however, they can develop Lyme disease.

People who work outside or spend time in woodland areas, where there is greater potential for exposure to tick bites, are most at risk of infection.

Lyme disease is a condition which progresses in stages:

  • A person will initially develop early localized lyme disease, in which the bacteria have not yet spread through the body. At this stage, which generally has its onset days or weeks after the tick bite, a persons symptoms will usually include a fever, fatigue, and a rash, called the Erythema Migrans rash, which has a distinctive bulls eye shape and affects around two thirds of people who develop Lyme disease. See this resource for more information on symptoms and treatment of .
  • If early localized Lyme disease is not successfully treated with antibiotics, such as doxycycline, in time, it will develop into early disseminated Lyme disease, spreading to other areas of the body. If this occurs, other oral or intravenous antibiotics will be needed oral antibiotics will be used in cases which are considered less severe. See this resource for more information on symptoms and treatment of .
  • What Happens At Your Appointment

    The GP will ask about your symptoms and consider any rash or recent tick bites you know about.

    Lyme disease can be difficult to diagnose. It has similar symptoms to other conditions and there’s not always an obvious rash.

    2 types of blood test are available to help confirm or rule out Lyme disease. But these tests are not always accurate in the early stages of the disease.

    You may need to be retested if you still have Lyme disease symptoms after a negative result.

    When Should I See My Healthcare Provider

    If you feel sick after having spent time in areas where ticks might live, you should make an appointment with your healthcare provider.

    If you received a Lyme disease diagnosis and you dont feel well after taking all of your antibiotics, contact your provider. This is especially true if you have symptoms like a stiff neck or mental confusion.

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    Is Lyme Disease An Arthropod Disease

    There is no definitive answer to this question as the research on Lyme disease is ongoing and constantly evolving. However, some experts believe that Lyme disease may be caused by an arthropod, such as a tick, which transmits the bacteria that causes the disease. Others believe that Lyme disease is not an arthropod disease, but is instead caused by a virus or other type of pathogen.

    Borrelia burgdorferi, a bacterium, causes Lyme disease, which causes inflammation. Blacklegged ticks can spread this bacterium to humans by biting them. When one or more joints in the body become swollen or painful as a result of Lyme arthritis, this is one of the most common manifestations. In some cases, inflammation can spread to the brain, causing damage to specific areas of the brain.

    What Are The Symptoms Of Post

    Pin on healing

    Doctors have known for years that they cannot rely on a physical exam to diagnose early Lyme disease unless they find an erythema migrans rash, Bells palsy, or heart block. Now, Rebman and colleagues from the Johns Hopkins University School of Medicine acknowledge that doctors also cannot count on a physical exam to diagnose Post-treatment Lyme disease syndrome .

    In their article published in the journal Frontiers in Medicine, the authors state, Results from the physical exam and laboratory testing our sample of patients with PTLDS did not show a pattern of significant objective abnormalities. However, the most notable exception was the higher rate of diminished vibratory sensation on physical exam among participants with PTLDS.

    Following treatment for Lyme disease, it is uncommon to find objective clinical manifestations in patients with PTLDS, according to the researchers. In fact, a much more likely scenario after treatment is the persistence or development of subjective symptoms without any residual or new objective manifestation.

    But the authors did discover a collection of symptoms among the Lyme disease patients which, when looked at as a whole, indicated the presence of problems post-treatment. For example, Although only found in a small subset of our sample , two participants met criteria for postural orthostatic tachycardia syndrome, an autonomic condition that has been previously reported following Lyme disease.


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    What Can I Expect Long Term If My Child Has Lyme Disease

    If Lyme disease is caught and treated early, most children will make a full recovery. Some children with Lyme disease go on to experience what’s called a post-infectious syndrome with symptoms that may include feeling fatigue, joint aches and pains, headaches, difficulty sleeping, and problems concentrating. Since the infection itself is gone by this time, doctors generally don’t prescribe antibiotics. Each child is different, but it’s not uncommon for symptoms of post-infectious syndrome to linger for months, or even years, and they can be made worse by stress or other illness. But most children do make a full recovery.

    Blacklegged, or deer, ticks are very small, so it helps to know what to look for when doing a tick check. Adults are about the size of sesame seeds and in the nymph or larva stage, they can be as tiny as a poppy seeds.

    How Can I Tell If Treatment Is Working

    If joint lameness is the presenting sign, improvement may be noted after 3-5 days starting antibiotics. A dogs response to therapy can be assessed by repeating the QC6 test six months after treatment is complete. Dogs that start with a moderate to high QC6 value typically show a 50% reduction or more in the QC6 at six months, indicating that treatment has been successful. Dogs that have a lower initial QC6 value may not show such dramatic reductions in the QC6 at six months, although the value should still be lower than the starting point if treatment has been successful.

    A persistently high QC6 suggests treatment may not have been complete or that the dog became reinfected after treatment was stopped.

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    How You Get Lyme Disease

    If a tick bites an animal carrying the bacteria that cause Lyme disease, the tick can become infected. The tick can then transfer the bacteria to a human by biting them.

    Ticks don’t jump or fly. They climb on to your clothes or skin if you brush against something they’re on. They then bite into the skin and start to feed on your blood.

    Generally, you’re more likely to become infected if the tick is attached to your skin for more than 24 hours. Ticks are very small and their bites are not painful, so you may not realise you have one attached to your skin.

    Study Confirms Memory Concentration Issues After Lyme Disease

    Long Haul Lyme Disease Risk Found: Even in Early Treated Patients | Johns Hopkins Rheumatology

    Many people with whatâs known as post-treatment Lyme disease â or PTLD â complain about problems with memory and concentration, which sometimes come with fatigue, muscle pain, insomnia, and depression.

    To understand potential changes in brain function that might explain these cognitive difficulties, researchers used specialized imaging techniques to compare the brains of 12 adults with PTLD and 18 adults with no history of Lyme disease.

    The researchers found changes in the white matter of the brains of those with PTLD. White matter is found in the deeper brain tissues and contains nerve fibers that are extensions of nerve cells.

    “We found that … white matter function increased while participants with PTLD were performing a cognitive task,” says lead investigator Cheri Marvel, PhD, an associate professor of neurology and psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine in Baltimore.

    “I think if patients heard this, they might feel validated that there is a biologic basis for their persistent symptoms, even if there is no good way to treat the cognitive difficulties yet,” she says. This may be similar to what patients with long COVID experience, Marvel says.

    The study was published online Oct. 26 in the journal PLOS One.

    âWe Could Begin to Connect the Dotsâ

    Those with PTLD performed more slowly on some of the memory tasks, although their slower speed did not affect the accuracy of their performance.

    Sign of Healing?

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    Lyme Disease: Signs And Symptoms

    This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. To view this licence, visit or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: .

    Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned.

    This publication is available at

    Posttreatment Lyme Disease Syndromes: Distinct Pathogenesis Caused By Maladaptive Host Responses

    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    Address correspondence to: Allen C. Steere, Massachusetts General Hospital, CNY 149/8301, 55 Fruit Street, Boston, Massachusetts 02114, USA. Phone: 617.726.1527 Email: .

    J Clin Invest.

    Lyme disease, which is epidemic in certain communities, primarily in the northeastern United States, is caused by the tick-borne spirochete Borrelia burgdorferi . When untreated, the disease usually occurs in stages with different manifestations at each stage . In the northeastern United States, the infection usually begins with a slowly expanding skin lesion, erythema migrans , often accompanied by nonspecific symptoms, including headache, myalgias, arthralgias, fever, malaise, and fatigue. Within weeks , neurologic or cardiac abnormalities may develop. Months later , usually following a latent period, intermittent or persistent monoarticular or oligoarticular arthritis commonly develops, lasting for several years, accompanied by minimal, if any, systemic symptoms. Rarely, patients have late neurologic involvement, characterized by a subtle encephalopathy or sensory polyneuropathy. Thus, in most patients, the natural history of Lyme disease, without treatment, is one of persistent infection for several years, with latent periods and changing system involvement.

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    Treatment Of Lyme Disease

    Early diagnosis and proper antibiotic treatment of Lyme disease is important and can help prevent late Lyme disease. The following treatment regimens reflect CDCs interpretation of the most current data for four important manifestations of Lyme disease. These regimens are consistent with guidanceexternal icon published by the by the Infectious Disease Society of America, American Academy of Neurology, and American College of Rheumatology.

    Some patients report persistent symptoms of pain, fatigue, or difficulty thinking even after treatment for Lyme disease. The state of the science relating to persistent symptoms associated with Lyme disease is limited, emerging, and unsettled.

    Additional researchexternal icon is needed to better understand how to treat, manage, and support people with persistent symptoms associated with Lyme disease. In light of these research gaps, recommendations for treatment of persistent symptoms in people previously treated for Lyme disease are not provided here.

    If you are interested in information on chronic Lyme diseaseexternal icon, see NIHs website.

    Links with this icon indicate that you are leaving the CDC website.

    Risk Factors For Post

    Lyme Disease Testing

    Youre at a greater risk for post-treatment Lyme disease syndrome if youre infected by the bite of a diseased tick. If the infection progresses to the chronic stage, your symptoms might continue for weeks, months, or even years after the initial tick bite.

    You may also be at a higher risk for these long-term symptoms if youre not treated with the recommended antibiotics. However, even people who receive antibiotic therapy are at risk. Because the cause of post-treatment Lyme disease syndrome is unknown, theres no way to determine whether it will progress to the chronic stage.

    Typically, the symptoms of post-treatment Lyme disease syndrome resemble those that occur in earlier stages. People with persistent symptoms often experience lingering episodes of:

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    How Does Lyme Disease Present For Different Age Groups

    There isnt one age group where Lyme presents more or less severely: Lyme disease presents similarly in babies, kids, and adults. However, Mordue notes that there is substantial variability of disease presentation and severity between people. In other words, two siblings who are both bitten by a tick while out in the woods may have very different symptoms. Children, however, are more likely to get it than adults since children typically spend more time outdoors, and because tall grasses are proportionally taller for young children.

    Fatigue, headache, and fever are common symptoms of early Lyme disease. Joint pain is another potential symptom: Some children may present with a swollen, painful joint as their first symptom of Lyme disease, though this is considered a later manifestation, Szantyr explains. While the knee is most commonly written about, it can be wrists, elbows, hips, ankles, even the TMJ. If your child is old enough to tell you something hurts, take note, write it on the calendar, check their temperature and remember what you have been doing and whether there is a possibility of tick exposure For younger children, notice if they are limping, if they are not playing in their usual way, if they seem a little less like themselves.

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    If My Animal Is Positive On The Assay Should He/she Be Treated For Lyme Disease

    If your animal is displaying clinical signs of Lyme disease and is positive on the Lyme Multiplex assay, it is advisable to discuss treatment options with your veterinarian. If your animal appears healthy, discuss the risks and benefits of treatment and develop a monitoring plan with your veterinarian.

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    Is It Possible For Lyme Disease To Be Misdiagnosed As Amyotrophic Lateral Sclerosis Are There Similarities In Symptoms Between These Two Diseases

    The question of a relationship between Lyme Disease and ALS first received significant academic attention when Dr. John Halperin who was then a neurologist at Stony Brook conducted a study in which he compared the frequency of blood test positivity to the agent of Lyme disease among patients with ALS to community controls. The results indicated a higher percentage of the ALS patients were seropositive for Lyme Disease. Since then, there have been isolated case reports both in the media and one or two in the academic literature indicating that a patient had been misdiagnosed with an ALS-like illness only later to be re-diagnosed and treated for Lyme disease with good clinical response. Although we suspect that there may be rare individuals who have symptoms similar to ALS but actually have proximal motor neuropathy caused by Lyme disease, the vast majority of patients with ALS are not thought to have Lyme disease as the cause of their serious disease. Clinical trials have been underway using antibiotics for ALS not because there is belief that ALS is caused by a microbe but because these antimicrobial agents have other properties as well, such as decreasing inflammation or decreasing glutamatergic excitotoxicity. The studies examining intravenous ceftriaxone as a treatment for ALS were not successful.

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    Your Test Was Not Sensitive Enough

    Alternative treatments for Lyme disease symptoms brings new hope to those suffering

    Many doctors and labs adhere diligently to the two-step tests for Lyme disease approved by the FDA and recommended by the CDC, which involves an initial enzyme-linked immunosorbent assay followed by a Western blot test. Both tests are designed to detect antibodies in the patients blood to the B. burgdorferi bacteria. According to the CDC, both must be positive for a patient to be diagnosed with Lyme disease.

    However, recent studies have raised concerns about the Lyme disease test accuracy, particularly the ELISA, which has been found to have a poor sensitivity rate, or ability to detect antibodies in the blood. Recent studies, in fact, report that the ELISA and Western blot can miss up to 60 percent of well-defined Lyme disease cases.

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    Chronic Lyme Dos And Don’ts

    Chronic Lyme disease is an ongoing Borrelia burgdorferi infection that can involve any body system or tissue. The infection produces a wide range of symptoms and signs, which can be debilitating for some patients. Common symptoms include severe fatigue, migratory musculoskeletal pain, headaches, and impaired memory. Unfortunately, chronic Lyme disease is complex and often misunderstood, which means that many patients will struggle to obtain the care they need to regain their health. Every patient concerned about Lyme disease and tick-borne illness should know the following.

    Lyme Disease And Other Tick Borne Illnesses

    Ticks carry a number of diseases, most notably Lyme Disease. They can create significant health risks for humans and companion animals.

    What diseases can ticks transmit?

    Ticks can transmit a number of diseases including:

    Which ticks transmit diseases? Any tick can transmit diseases, but certain diseases are linked with certain ticks. All of the above illnesses are associated with ticks that are present in New Jersey.

    What is Lyme Disease? Lyme Disease is the most common tick borne illness in the United States. It is transmitted by the deer tick. A tick has to be present on the skin for at least about 48 hours to transmit the infection, so detection and removal of ticks is important in prevention.

    How is Lyme disease treated? Lyme disease can be treated with antibiotics. First-line treatments include doxycycline, amoxicillin, or cefuroxime for adults and children. Sometimes IV antibiotics are used if the Lyme disease is impacting the heart or brain. Once a patient is showing improvement, they may be switched from IV to oral antibiotics. The treatment is 7 to 14 days. If a patient has developed Lyme arthritis, which can be a late-stage symptom of Lyme disease, they may have a longer course of oral antibiotics.

    What are signs of tick borne illnesses?

    Signs and symptoms of tick borne illnesses vary with the illness and can show up 7 to 21 days after exposure. They include:

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