Critical Appraisal Of Individual Studies
The included systematic review was critically appraised by one reviewer using AMSTAR II, the non-randomized study was assessed using the ROBINS-I Tool, and guidelines, were assessed with the AGREE II instrument. Summary scores were not calculated for the included studies rather, a review of the strengths and limitations of each included study were described narratively.
What Is Lymepak And How Does It Work
Lymepak is a prescription medicine used for the treatment of early Lyme disease due to a bacteria known as Borrelia burgdorferi in adults and children 8 years of age and older weighing 99 pounds and above.
It is not known if Lymepak is safe and effective in children less than 8 years of age or weighing under 99 lbs .
For Memory Concentration And Focus
Improving memory is a challenge. In Lyme disease, short-term memory problems and word-retrieval problems are common. These often improve substantially with appropriate antibiotic therapy. Over time, most patients regain their cognitive function.
When memory is a problem, consider that this could due to a primary problem with attention or with mood. An individual who can’t focus won’t be able to remember because he/she didn’t “attend” to the item in the first place. This happens to all of us when we hear someone’s name at a party if we don’t focus on the name and perhaps make a mental association to the name to enhance memory storage, we will forget that name within minutes. Patients with depression often experience problems with memory and verbal fluency when the depression is resolved, the memory and verbal fluency typically resolve as well.
- Medications: Attention can be improved with certain medications, such as bupropion , atomoxetine , modafinil , or stimulants . Medications that temporarily slow cognitive decline in Alzheimer’s disease or memantine ) have not been studied in Lyme disease.
- There is some evidence that online brain training programs can enhance concentration or processing speed.
- Neurofeedback may be helpful in improving attention, as well as in improving sleep and reducing pain. This has been studied for migraines, fibromyalgia, and ADHD.
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Is Lymepak Safe To Use While Pregnant Or Breastfeeding
- Lymepak, like other tetracycline-class antibacterial drugs, may cause discoloration of deciduous teeth and reversible inhibition of bone growth when administered during the second and third trimester of pregnancy.
- Available data from published studies over decades have not shown a difference in major birth defect risk compared to unexposed pregnancies with doxycycline exposure in the first trimester of pregnancy.
- There are no available data on the risk of miscarriage following exposure to doxycycline in pregnancy.
- Based on available published data, doxycycline is present in human milk.
- There are no data that inform the levels of doxycycline in breastmilk, the effects on the breastfed infant, or the effects on milk production.
- Because there are other antibacterial drug options available to treat Lyme disease in lactating women and because of the potential for serious adverse reactions, including tooth discoloration and inhibition of bone growth, advise patients that breastfeeding is not recommended during treatment withLymepak and for 5 days after the last dose.
Side Effects Of Doxycycline For Dogs
Dogs generally tolerate doxycycline well, but it is always a good idea to understand the possible side effects of a drug before you give your dog a new medication. The most common side effects are symptoms of GI upset, such as vomiting and diarrhea. Severe GI symptoms could be a sign of a doxycycline overdose, so be sure to call your vet.
Tetracycline antibiotics like doxycycline can cause skeletal limb deformities in developing puppies in utero, posing a potential risk for pregnant mothers. In some cases, the benefits of using doxycycline outweigh the potential risks for pregnant mothers, but be sure to let your vet know if your dog is pregnant prior to treatment.
If your dog has a history of allergic reactions to antibiotics, especially antibiotics in the tetracycline family, make sure you mention this to your vet, as doxycycline could trigger a dangerous allergic reaction.
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Can Lyme Disease Be Prevented Or Avoided
The best way to prevent Lyme disease is to avoid being bitten by ticks. When you are outdoors, follow these guidelines:
- Avoid areas that are wooded, brushy, or have tall grass.
- Walk in the center of trails.
- Use an insect repellent with at least 20% DEET. It can be put on clothing or sparingly on the skin. Dont apply it to the face or hands of children.
- Treat clothing, tents, or other gear with repellents containing 0.5% permethrin.
- Wear light-colored clothing. This makes it easier to see and remove ticks from your clothes.
- Wear a long-sleeved shirt and long pants. Tuck your pant legs into your socks or boots for added protection.
After you get home, check everything and everyone for ticks.
- Bathe or shower as soon as you can to wash off any ticks that have not attached to you.
- Check your entire body for ticks. Use a mirror for places you cant see. Check your children and your pets. Common tick locations include the back of the knees, groin area, underarms, ears, scalp, and the back of the neck.
- Check any gear you used, including coats, backpacks, or tents.
Tumble dry clothes or blankets on high heat in the dryer for 10 to 15 minutes. This should kill any ticks. If clothes are dirty, wash them in hot water and dry on high heat for 60 minutes.
What Are The Uses Of Doxycycline For Dogs
Doxycycline is typically used to treat bacterial infections and infections caused by microorganisms. It is not effective against viral infections or fungal infections. Your vet might prescribe doxycycline to treat a present infection, or as precaution against a secondary bacterial infection, as is often the case with viral infections like canine parvovirus that leave dogs vulnerable to secondary bacterial infections.
Some examples of conditions veterinarians treat with doxycycline for dogs include:
- Respiratory infections
If your dogs condition is not on this list, dont worry. Doxycycline has a broad range of applications and can help treat many different types of bacterial infections and microorganisms that affect dogs.
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Doxycycline Dosage For Lyme Disease Prevention
You have been bitten by a tick and do not know what to do? First of all, visit your doctor. He will propose an appropriate treatment that will help to prevent Lyme disease.However, not every doctor knows how to treat this disease in the early and late stages. So what is the doxycycline dosage for Lyme disease prevention after being bitten by a tick?
When a patient who has been recently bitten by a tick reports to a doctor, the doctor usually prescribes doxycycline at a dose of 200mg per day, divided into two portions 100mg in the morning and 100mg in the evening. Is this, however, a sufficient dose to stop the possible spread of Lyme disease in our body?
In this article, we will focus on the treatment proposed by the International Lyme and Associated Diseases Society . As well as for the treatment of fresh Lyme disease or doxycycline therapy just after a tick bite to prevent disease.
Other Uses For This Medicine
Doxycycline may also be used for the treatment of malaria. It may also be used to treat Lyme disease or to prevent Lyme disease in certain people who have been bitten by a tick. It may also be used to prevent infection in people who were sexually attacked. Talk to your doctor about the possible risks of using this medication for your condition.
This medication is sometimes prescribed for other uses ask your doctor or pharmacist for more information.
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Dont Let Lyme Stop You
Lyme Disease is one of the most misunderstood diseases. So misunderstood, in fact, that even doctors have a difficult time detecting and diagnosing Lyme Disease. Furthermore, once it has been diagnosed, there isnt a clear treatment protocol for doctors to follow. Thats why you need to choose a medical clinic with Lyme Disease specialists who understand the difficulty of living with this disease.
Our medical detectives have years of experience in identifying this disease where other doctors have failed, and in treating even the most trying cases. Dont settle for doxycycline find real relief with our clinic today. For more information on Lyme Disease, or to schedule a consultation, contact us at Serenity Health Care in Milwaukee, Wisconsin.
How Should This Medicine Be Used
Doxycycline comes as a capsule, delayed-release capsule, tablet, delayed-release tablet, and suspension to take by mouth. Doxycycline is usually taken once or twice a day. Drink a full glass of water with each dose. If your stomach becomes upset when you take doxycycline, you may take it with food or milk. However, taking doxycycline with milk or food may decrease the amount of medication absorbed from your stomach. Talk with your doctor or pharmacist about the best way to take doxycycline. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxycycline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the delayed-release tablets and the Acticlate CAP capsules whole do not split, chew, or crush them.
If you cannot swallow certain delayed-release tablets whole, carefully break up the tablet and sprinkle the contents of the tablet on a spoonful of cold or room temperature applesauce. Be careful not to crush or damage any of the pellets while you are breaking up the tablet. Eat the mixture right away and swallow without chewing. If the mixture cannot be eaten right away it should be discarded.
Shake the suspension well before each use to mix the medication evenly.
Continue to take doxycycline even if you feel well. Take all the medication until you are finished, unless your doctor tells you otherwise.
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Lyme Disease: Symptoms & Side Effects
Lyme disease is a tick-born illness with over 150 symptoms. Lyme disease symptoms usually involve multiple systems. There are three stages of Lyme disease: early localized, early disseminated, and late persistent. If left untreated, it may progress into long-term disabilities. However, it is important to note that Lyme disease can lie dormant in your body for a prolonged period of time, and will invade when your immune system is compromised.
- Irritable bladder
- Upset stomach
- Pain in eyes, or swelling around eyes
- Oversensitivity to light
- Buzzing in ears
- Pain in ears, oversensitivity to sound
- Ringing in one or both ears
- Unexplained weight gain or loss
- Extreme fatigue
- Unexplained fevers
- Continual infections
- Symptoms seem to change, come and go
- Pain migrates to different body parts
- Early on, experienced a flu-like illness, after which you have not since felt well
- Twitching of facial or other muscles
- Facial paralysis
- Tingling of nose, cheek, or face
- Stiff or painful neck, creaks and cracks
- Jaw pain or stiffness
- Memory loss
- Confusion, difficulty in thinking
- Difficulty with concentration or reading
- Going to the wrong place
- Speech difficulty
- Stammering speech
- Any joint pain or swelling
- Stiffness of joints, back, neck
- Muscle pain or cramps
- Burning or stabbing sensations in the body
- Weakness or partial paralysis
- Numbness in body, tingling, pinpricks
- Poor balance, dizziness, difficulty walking
- Increased motion sickness
How Long Doxycycline Stays In Your System
Doxycycline has a half-life of 14-24 hours, depending on factors such as age, weight, and dosage.
A half-life is the time it takes for the substance in your body to be reduced to half of the strength of the original dosage.
If your dose of doxycycline is 150 mg, for example, then it will take approximately 18-19 hours before it is reduced in the body by half and about 28-42 hours for the medication to be completely out of your system.
The half-life of your medication matters when it comes to other drugs or supplements you take that may interact with it, or when you want to consume substances that may alter how your body responds.
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How To Give Doxycycline To Dogs
Doxycycline has a high bioavailablity, which means it is easily absorbed by the canine body. It can be given with or without food, unlike other types of tetracycline, as long as the dog has access to fresh water. The best way to give doxycycline to your dog is to follow your veterinarians instructions, as your veterinarian has access to detailed scientific literature about doxycycline uses, side effects, dosages, and drug interactions that most owners do not.
Note: This article is intended for informational purposes only. Contact your veterinarian for questions regarding your dogs case or with any concerns about doxycycline for dogs.
AKC is a participant in affiliate advertising programs designed to provide a means for sites to earn advertising fees by advertising and linking to akc.org. If you purchase a product through this article, we may receive a portion of the sale.
What Are The Side Effects Of Lyme Disease Treatments
Antibiotics, like all medications, have the potential for side effects. Any antibiotic can cause skin rashes, and if an itchy red rash develops while on antibiotics, a patient should see their physician. Sometimes symptoms worsen for the first few days on an antibiotic. This is called a Herxheimer reaction and occurs when the antibiotics start to kill the bacteria. In the first 24 to 48 hours, dead bacterial products stimulate the immune system to release inflammatory cytokines and chemokines that can cause increased fever and achiness. This should be transient and last no more than a day or two after the initiation of antibiotics.
The most common side effect of the penicillin antibiotics is diarrhea, and occasionally even serious cases caused by the bacteria Clostridium difficile. This bacterial overgrowth condition occurs because antibiotics kill the good bacteria in our gut. It can be helpful to use probiotics to restore the good bacteria and microbiome balance.
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Tips On Taking Doxycycline
he standard antibiotic treatment for Lyme disease is a three week course of doxycyline.
It aims to slow down or kill bacteria by inhibiting its protein production, and can induce a number of side effects such as diarrhoea, nausea, vomiting, and an increased risk of sunburn.
If you are prescribed with doxycycline, there are a few simple things you can do to help manage any side effects you might feel and to may sure that the antibiotic is working as effectively as possible.
What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light and excess heat and moisture .
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
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Summary Of Study Characteristics
Additional details regarding the strengths and limitations of included publications are provided in .
Systematic Review with Meta-Analysis
The review is unclear regarding whether study selection was conducted in duplicate if the reviewers did not conduct study selection in duplicate then this could introduce bias into the review, with reduced quality and confidence in its results. Grey literature was not searched and content experts were not consulted, which may have omitted relevant data and introduced publication bias. This omission is of particular importance since publication bias was not assessed. The sources of funding for each included trial were not discussed and risk of bias from the selection of the reported result from multiple measurements or analyses was not assessed. These review characteristics may increase bias in: study selection search strategy risk of bias assessments and their impact on the meta-analysis, interpretation of results, and discussion sources of funding and conflicts of interest, which therefore decrease the confidence in the results of the systematic review.
Outcome measurement may have been influenced by knowledge of received intervention since the outcome assessors were aware of the intervention received by study participants and may therefore decrease confidence in the results of the study.
Guidelines With Unclear Methodology
- CHEO. Prophylaxis of Lyme disease in pediatric patients. 2018.
- MukkadaS, BuckinghamSC. Recognition of and prompt treatment for tick-borne infections in children. Infect Dis Clin North Am. 2015 29:539555.
- OnyettH. Lyme disease in Canada: focus on children. Paediatr Child Health. 2014 19:379388.
- SmithGN, GemmillI, MooreKM. Management of tick bites and lyme disease during pregnancy. J Obstet Gynaecol Can. 2012 34:10871091.
- SzulzykT, FlisiakR. Lyme borreliosis. Ann Parasitol. 2012 58:6369.
- LopezSMC, CampfieldBT, NowalkAJ. Oral management for pediatric Lyme meningitis. J Pediatric Infect Dis Soc. 2018.
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Are There Any Potential Side Effects
The most common side effects include vomiting, diarrhea, and lack of appetite, and these signs may be eased by giving the medication with food. Increases in liver enzymes on bloodwork may also occur, more commonly in dogs than in cats.
This medication may also make your pets skin more sensitive to sunlight and therefore sunburn, especially of the hairless areas like the nose, eyelids, and ears is possible.
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
More serious side effects include liver failure characterized by a yellowing of the skin, as well as seizures, bleeding, behavior changes, trouble swallowing, or an upset stomach when doxycycline has not been just given. Contact your veterinarian if any of these serious side effects occur.