New Paradigms In Lyme Disease Treatment

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A New Book New Paradigms In Lyme Disease Treatment: 10 Top Doctors Reveal Healing Strategies That Work Unveils New Evidence

Dallas, Texas October 19, 2016

Chronic Lyme disease was once thought of as a controversial health condition, but has gained increasing acceptance in the scientific community as a worldwide pandemic. In fact, it is now recognized as the fastest growing infectious disease in the United States and Canada, with over 300,000 new cases every year, according to the Centers for Disease Control. However, even with increased recognition and ongoing scientific research, it remains largely incurable and an enigma to the medical profession. Thousands of Lyme disease patients are still desperately awaiting help.

Yet recent years have brought tremendous progress in Lyme disease treatment. In a new book, New Paradigms in Lyme Disease Treatment: 10 Top Doctors Reveal Healing Strategies that Work, ten leading integrative doctors share some of the newest evidence-based treatments for chronic Lyme disease.

When it is caught early, Lyme disease can be effectively treated with 4-6 weeks of antibiotics, but in many cases, it becomes chronic, at which time complex, long-term treatment regimens are required. Yet few doctors are trained to adequately recognize and treat chronic Lyme, which mimics many other conditions such as Chronic Fatigue Syndrome , fibromyalgia, arthritis, Parkinsons, lupus and Multiple Sclerosis.

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Tick Immunity And The Microbiome

The role of the tick and vertebrate host microbiome on transmission of organisms is just beginning to be understood . Studies in mosquitoes have associated the human skin microbiome with susceptibility to bites by the insects . Specific metabolites released by the microbiome are able to attract mosquitoes . Repellents based on modulating the skin microbiome for insect repellency are already in development for Triatoma infestans and Rhodnius prolixus , two vectors of Chagas disease. Whether similar effects to repel Ixodes ticks could be engendered by changes in the mouse microbiome is unknown.

The tick immune system plays an important role in shaping the tick microbiome. Recently, a tick protein called PIXR, has been shown to alter the gut microbiome, metabolome and immune responses . Interestingly, these alterations influence the spirochete persistence in the tick. Similarly, Anaplasma phagocytophilum, another pathogen transmitted by ticks, has been shown to induce a tick protein, Ixodes scapularis antifreeze glycoprotein , in order to efficiently colonize the tick through a mechanism that perturbs the tick gut microbiome . Altering the tick microbiome could potentially be a way to disrupt the tick gut peritrophic membrane and to stop the B. burgdorferi transmission .

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New Paradigms In Lyme Disease Treatment: 10 Top Doctors Reveal Healing Strategies That Work Paperback

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Connie StrasheimNew Paradigms in Lyme Disease Treatment: 10 Top Doctors Reveal Healing Strategies That Work, Paperback

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“Connie Strasheim’s book is a MUST-READ for anyone who has Lyme disease for those who suspect that they might have it or who are concerned about exposure to it, and for those who have friends or family members with it. It is packed with plenty of NEW, useful and easy-to- understand information about Lyme, its coinfections and various co-conditions. For this book, Connie interviewed ten leading Lyme specialists, including one from Germany, one from Canada and eight from the USA -all of which have an integrative approach to treatment. The experts all agree that certain treatment steps are essential for recovery, but all have a unique treatment approach and provide their own pearls of wisdom. I congratulate Connie for a job VERY well done ” W. Lee Cowden, MD, MD Chairman, Scientific Advisory Board Academy of Comprehensive Integrative Medicine

Genetic Engineering For Reservoir And Vector Incompetence

The advent of CRISPR/Cas technologies have made targeted engineering of mice feasible. By incorporating the CRISPR/Cas machinery into an engineered cassette called a gene-drive and inserting it into the chromosome, animals can pass along the engineered trait in a dominant, non-Mendelian pattern as the inserted gene will create a copy of itself onto the other chromosome. Investigators have proposed using this tool to create B. burgdorferi resistant mice carrying a gene to express an anti-OspA antibody . Proof of principle studies are being carried out in mice without the use of the gene drive, but ultimately, use of gene drive technology could prove to be a low-cost mechanism for changing reservoir competence of an entire population of mice. However, the path to using this technology will be difficult due to concerns about the ability to control unforeseen events caused by a self-replicating, engineered mutation.

A similar genetic engineering strategy could be undertaken with a focus on ticks. Engineering ticks to be of a single sex to reduce tick populations or elimination of specific proteins required for vector competence could be an effective strategy for controlling tick transmitted diseases. Similar strategies have been proposed for mosquitos in the control of dengue virus . However, Ixodes tick biology with its 2-year cycle, may make tick gene drive approaches very challenging.

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Sorry Some Books Are Currently Unavailable

A book might be showing as ‘out of stock’ for a number of reasons. It could be that it’s a really popular title and we’re simply waiting for the publisher to print and supply more stock. Sometimes, it may be the case that the book is no longer in publication.

However, there are a few other factors that are currently having an impact on product availability. As a result of the COVID-19 pandemic, many of our suppliers are reporting disruption because of staff shortages and transit limitations. And Brexit related restrictions / freight policy changes are causing further logistical delays.

If you’d like us to email you if / when this book is back in stock, please close this window and click the ‘Notify Me’ button.

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New Paradigms In Lyme Disease Treatment: 10 Top Doctors Reveal Healing Strategies That Work

New Book by Connie Strasheim, Steven Harris MD

Connie Strasheims book is easy-to- understand information about Lyme, its coinfections and various co-conditions. For this book, Connie interviewed ten leading Lyme specialists, including one from Germany, one from Canada and eight from the USA -all of which have an integrative approach to treatment. The experts all agree that certain treatment steps are essential for recovery, but all have a unique treatment approach and provide their own pearls of wisdom. I congratulate Connie for a job VERY well done! W. Lee Cowden, MD, MDChairman, Scientific Advisory Board Academy of Comprehensive Integrative Medicine

Targeting Nutritional Vulnerabilities Of B Burgdorferi

B. burgdorferi has a very spare genome and is highly dependent upon its environment for providing critical nutrients. For example, B. burgdorferi is not able to synthesize fatty acids and cholesterol, and rely completely on host lipids notably present in the blood meal. Moreover, it manipulates the production level of specific amino-acids in the tick, suggesting a critical need for the bacteria to highjack the tick metabolism pathways . This creates unique vulnerabilities of the organism to the lack of specific nutrients and/or may allow targeting of pathways that are redundant in other bacteria, but limited in B. burgdorferi. Chakraborti et al. have shown that targeting the purine salvage pathway of B. burgdorferi with inhibitory nucleoside analogs resulted in killing of the organism .

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