Chronic Lyme Disease Vs Acute And Late Stage Lyme
One reason chronic Lyme disease is harder to detect and treat than Lyme at earlier stages is that chronic Lyme disease symptoms are more wide-ranging and varied. Chronic Lyme disease can cause symptoms of early Lyme disease such as fatigue and muscle aches to recur, but it can also cause new symptoms that affect different parts of the body.
Natural Methods To Reduce Or Eliminate Lymes Disease Symptoms
Lyme Disease has a much better shot of being fixed than Alzheimers. There are doctors who are finding some natural methods of treating Lyme Disease. Two of those doctors are Stephen Harrod Buhner and Bill Rawls.
As with all natural healing methods, both doctors recommend a very healthy diet. Eating lots of fruits and vegetables and avoiding processed foods and sugars are important. Ridding your body of toxins and filling it up with nutrients allows your immune system to function at its optimum level.
Another recommendation the two doctors provide is the use of plant-based oils. The oils serve 3 purposes:
- Fighting the bacteria
- Detoxify your body
Four of these essential oils are very effective in promoting antimicrobial activity:
Extended Antibiotics For The Treatment Of Post
Three research groups have examined prospectively the effectiveness of prolonged antibiotic courses for post-Lyme disease syndromes., All trials had strict entrance criteria similar to the aforementioned definition of PLDS. The Klempner and colleagues study reported 2 parallel trials in which their cohort of 129 subjects was divided into seropositive and seronegative arms. Subjects randomized to treatment groups received 30 days of intravenous ceftriaxone followed by 60 days of oral doxycycline. Those randomized to the placebo arm received IV placebo for 30 days, followed by an oral placebo for 60 days. The primary outcome was health-related quality of life as assessed by standardized instruments . These instruments were administered at baseline, and then 30, 90, and 180 days. There was no difference in any outcome measure between placebo and treatment groups in either the seropositive or seronegative arm, or in a detailed battery of neuropsychological tests that was published subsequently. Although all patients had complained of cognitive dysfunction at baseline , objective measures of cognitive function, such as memory and attention, were normal compared with age-referenced normative data. Depression, anxiety, and somatic complaints improved in both the antibiotic and placebo arms groups between baseline and day 180.
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What Is Chronic Lyme Disease
Lyme disease is an infection caused by the bacterium Borrelia burgdorferi. In the majority of cases, it is successfully treated with oral antibiotics. In some patients, symptoms, such as fatigue, pain and joint and muscle aches, persist even after treatment, a condition termed Post Treatment Lyme Disease Syndrome .
The term chronic Lyme disease has been used to describe people with different illnesses. While the term is sometimes used to describe illness in patients with Lyme disease, it has also been used to describe symptoms in people who have no clinical or diagnostic evidence of a current or past infection with B. burgdorferi . Because of the confusion in how the term CLD is employed, and the lack of a clearly defined clinical definition, many experts in this field do not support its use.
Lyme Disease In Dogs: Symptoms And Treatment
Reviewed and updated on April 14, 2020 by Rania Gollakner, DVM
Lyme disease in dogs is one of the most common tick-transmitted diseases in the world, but it only causes symptoms in 5-10% of affected dogs. So some dogs may have it, but never show symptoms.
Transmission of Lyme disease has been reported in dogs throughout the United States and Europe, but its most prevalent in the upper Midwestern states, the Atlantic seaboard and the Pacific coastal states.
However, the disease is spreading and becoming more common throughout the United States. Heres some info about the causes and prevention of Lyme disease, as well as the symptoms you should look for and treatment options.
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Importance Of The Study
The LymeProspect study shows that some Lyme patients remain limited in their physical and social functioning after treatment with antibiotics. In addition, fatigue, pain and concentration problems are reported more often by people with Lyme disease than by people without this disease: about 27% of the Lyme patients and 21% to 23% of the people without this disease. Also, the complaints of the Lyme patients were more severe. It is likely that such long-term symptoms may be the result of Lyme disease, but only in a small but substantial proportion of patients. It is important to acknowledge persistent symptoms and to obtain a better understanding of the causes of these symptoms. This can help prevent complaints and improve treatment.
What To Do About Lymes Disease Symptoms
Your best shot at fighting Lyme Disease is if you catch it early. Many doctors have had success treating Lymes Disease symptoms with antibiotics such as doxycycline, amoxicillin, cefuroxime axetil. Of course doctors will prescribe different amounts of these antibiotics depending on the health and age of the patient. Here are some general guidelines published by the CDC:
Notice that many of the treatments only last 2-3 weeks. Long-term antibiotic used to treat Lymes Disease symptoms may lead to many other complications. Once the condition becomes chronic, antibiotics may not be all that effective.
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Discovering New Tickborne Diseases
CDC is partnering with the Minnesota Department of Health, Mayo Clinic, Tennessee Department of Health, and Vanderbilt University to obtain up to 30,000 clinical specimens from patients with suspected tickborne illness over a 3-year period. CDC will use advanced molecular detection methods to identify tickborne bacteria that may be the cause of these patients illnesses. Already, investigators have used AMD to sequence the full genome of a newly discovered bacteria, Borrelia mayonii, which is another cause of Lyme disease in upper Midwestern states.
Using advanced molecular detection techniques, CDC researchers analyzed over 13,000 leftover samples for the presence of bacteria from patients who were suspected of having tickborne illness. Twelve tickborne species of bacteria that cause illness in people were detected, including two not previously associated with human illness. This large-scale study involving researchers from the Minnesota Department of Health, Mayo Clinic, Tennessee Department of Health, and Vanderbilt University, showed that a single advanced molecular detection test can be used to:
- Detect tickborne bacterial pathogens in clinical samples
- Discover bacteria not previously associated with human infection, that are likely transmitted to humans by tick bite
- Identify tick-transmitted bacterial co-infections
- Understand which bacterial infections can cause symptoms that may be confused with tickborne diseases
Ongoing Symptoms Of Lyme Disease
A few people who are diagnosed and treated for Lyme disease continue to have symptoms, like tiredness, aches and loss of energy, that can last for years.
It’s not clear why this happens to some people and not others. This means there’s also no agreed treatment.
Speak to a doctor if your symptoms come back, or do not improve, after treatment with antibiotics.
The doctor may be able to offer you further support if needed, such as:
- referral for a care needs assessment
- telling your employer, school or higher education institution that you require a gradual return to activities
- communicating with children and families’ social care
Page last reviewed: 05 July 2021 Next review due: 05 July 2024
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Has Niaid Looked At Whether Infection Persists After Antibiotic Therapy
Several recent studies suggest that B. burgdorferi may persist in animals after antibiotic therapy. In one study, NIAID-supported scientists found that remnants of B. burgdorferi remained in mice after antibiotic treatment. Another team of NIAID-supported investigators found that intact B. burgdorferi persist in nonhuman primates after antibiotic treatment. It was not possible to culture these bacteria and it is not clear whether they are infectious. More recent work by Hodzic et al. replicated the earlier finding of persisting DNA but non-cultivatable B. burgdorferi after antibiotic treatment using a mouse model. In 2017, scientists at the Tulane National Primate Research Centers, funded in part by an NIH research resources grant, reported evidence of persistent and metabolically active B. burgdorferi after antibiotic treatment in rhesus macaques.
In a first-of-its-kind study for Lyme disease, NIAID-supported researchers have used live, disease-free ticks to see if Lyme disease bacteria can be detected in people who continue to experience symptoms such as fatigue or arthritis after completing antibiotic therapy). This study remains underway.
Arthritis Caused By Lyme Disease
There are many causes for arthritis, and your veterinarian will focus on differentiating arthritis initiated by Lyme disease from other inflammatory arthritic disorders, such as trauma and degenerative joint disease.
Immune-mediated diseases will also be considered as a possible cause of the symptoms. X-rays of the painful joints will allow your doctor to examine the bones for abnormalities.
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Seek Medical Care Early To Prevent Lyme Disease From Progressing
Its easy to get bit by a tick and not know it. Most people dont feel a tick on their skin or the bite. Checking your skin for ticks after spending time outdoors can help you find a tick and remove it.
Removing a tick can prevent Lyme disease. A tick must be attached to your skin for at least 36 hours to infect you with the bacteria that cause Lyme disease.
Its not always possible to find a tick, so its important to pay close attention to your skin. If you notice any signs of Lyme disease or develop a rash, get medical care right away. Ticks can cause other serious diseases, such as Rocky Mountain spotted fever.
Related AAD resources
ImagesImage 1: Centers for Disease Control and Prevention, Public Health Image Library, Last accessed May 11, 2017.
Images 2, 3, and 7: Used with permission of the Journal of the American Academy of Dermatology. J Am Acad Dermatol. 2011 64:619-36.
Image 6: Used with permission of the American Academy of Dermatology National Library of Dermatologic Teaching Slides.
ReferencesBhate C and Schwartz RA.
Lyme disease: Part I. Advances and perspectives. J Am Acad Dermatol. 2011 64:619-36.
Lyme disease: Part II. Management and prevention. J Am Acad Dermatol 2011 64:639-53.
Centers for Disease Control and Prevention:
Signs and symptoms of untreated Lyme disease. Page last updated October 26, 2016. Last accessed May 2, 2018.
Lyme disease: transmission. Page lasted updated March 4, 2015. Last accessed May 2, 2018.
Kidney Damage Caused By Lyme Disease
More serious complications, although uncommon, include:
Damage to the kidneys
Rarely, heart or nervous system disease 1,2
Lyme disease sometimes leads to glomerulonephritisthe inflammation and accompanying dysfunction of the kidney’s glomeruli .
Eventually, kidney failure may set in as the dog begins to exhibit signs such as vomiting, diarrhea, lack of appetite, weight loss, increased urination and thirst, and abnormal fluid buildups that can appear as swollen limbs.
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What Happens If You Go Untreated For Lyme Disease
If untreated, Lyme disease can progress to chronic Lyme disease or stage 3 of Lyme disease. Stage 3 Lyme disease occurs months to years after the initial infection or a period of latency. Most patients presenting with the late disease do not have erythema migrans because the rash urges the patient to seek treatment earlier.
Acute Lyme Arthritis Presenting In Bilateral Hips Of An Elderly Patient: A Case Report
Lawrence M Asprec*1, Mitchell K Freedman2, Jeffrey A Gehret3 and George W Young3
1Senior Resident in Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital at Sidney Kimmel Medical College, Philadelphia, USA
2Medical Director of Physical Medicine and Rehabilitation, Associate Professor, Rothman Orthopaedic Institute, 925 Chestnut Street, 5th Floor, Philadelphia, USA
3Department of Physical Medicine and Rehabilitation, Division of Pain Management, Rothman Orthopaedic Institute, 925 Chestnut Street, 5th Floor, Philadelphia, USA
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Treatment Of Lyme Disease
Although all stages of Lyme disease respond to antibiotics, early treatment is more likely to prevent complications.
Antibiotics such as doxycycline, amoxicillin, or cefuroxime, taken by mouth for 2 to 3 weeks, are effective during the early stages of the disease. If early disease is localized, people may need treatment for only 10 days. If people cannot take any of these drugs, azithromycin is sometimes used but is less effective. Usually, doxycycline is not given to children under 8 years old or to pregnant or breastfeeding women.
Antibiotics can also help relieve many of the symptoms of Lyme disease.
For arthritis due to Lyme disease, antibiotics such as amoxicillin, cefuroxime, or doxycycline are given by mouth for 28 days, or ceftriaxone is given intravenously for 28 days.
Antibiotics eradicate the bacteria and, in most people, relieve arthritis. However, arthritis sometimes lasts even after all the bacteria are gone because inflammation continues. Even after successful antibiotic treatment, some people still have other symptoms such as fatigue, headache, and mental problems.
Nonsteroidal anti-inflammatory drugs , such as aspirin or ibuprofen, may relieve the pain of swollen joints. Fluid that collects in affected joints may be drained. Using crutches may help.
Clinical Approach To Patients With A Chronic Lyme Disease Diagnosis
Even if CLD lacks biological legitimacy, its importance as a phenomenon can be monumental to the individual patient. This is because many if not most patients who believe they have this condition are suffering, in many cases for years. Many have undergone frustrating, expensive, and ultimately fruitless medical evaluations, and many have become quite disaffected with a medical system that has failed to provide answers, let alone relief.
Beyond this generalization, patients referred for CLD have heterogeneous medical, social, and educational backgrounds. Furthermore, there is great variation in their commitment to a CLD diagnosis. Some patients are entirely convinced they have CLD, they request specific types of therapy, and they are not interested in adjudicating the CLD diagnosis. By contrast, others are not particularly interested in CLD per se, and are content to move on to a broader evaluation. In the authors experience most patients fall somewhere in betweena certain amount of time must be spent reviewing past experiences and past laboratory tests, then explaining why Lyme disease may not account for their illnesses.
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Diagnostic Tests/lab Tests/lab Values
Lyme disease is diagnosed based on symptoms, physical findings , and the possibility of exposure to infected ticks. Laboratory testing is helpful in the later stages of disease.
Diagnosis of any infectious disease requires a combination of clinical experience and assessment by the doctor and understanding of the lab tests and their limitations. Laboratory tests are rarely definitive and all tests have a proportion of results which are false-positive and false negative . When tests are done in places where the disease is rare or absent , many positive tests will be falsely positive.
The tests to diagnose Lyme disease are technically complex and require specialist expertise. It is important for people who want to be tested to make sure the laboratory that performs the test is reliable.
Lyme disease is most commonly diagnosed by a screening test called ELISA and this is then confirmed using a western blot test. Both of these tests detect antibodies that are produced by the immune system of someone with Lyme disease.
Lyme disease can also be diagnosed by testing a sample of the skin lesion by nucleic acid testing or culture.
What If A Tick Bites My Dog
The more ticks in your region, the likelier it is that your furry pal will bring them home.
Your dog is much more likely to be bitten by a tick than you are. And where Lyme disease is common, up to 25% of dogs have had it at some point.
About 10% of dogs with Lyme disease will get sick. 7-21 days after a tick bite, your dog might seem like theyâre walking on eggshells. They also might have a fever and enlarged lymph nodes. Plus, they might seem tired. Dogs also get antibiotics for Lyme.
What if my dog brings ticks into my home?
Use a tick control product on your pet to prevent Lyme disease. Also, have your dog vaccinated against Lyme.
Check your dogâs whole body each day for bumps. If you notice a swollen area, see if thereâs a tick there. If you find a tick, wear gloves while you use tweezers to separate it from your dog. Then, put it in soapy water or alcohol, or flush it down the toilet.
Use alcohol to clean the spot on your dog where the tick was attached. Keep an eye on that spot, and also on your dog to make sure theyâre behaving normally. If you notice any changes, check with your vet.
John Aucott, MD, assistant professor of medicine, Johns Hopkins University School of Medicine director, Johns Hopkins Lyme Disease Clinical Research Center.
Morbidity and Mortality Weekly Report: âVital Signs: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004-2016.â
American College of Rheumatology.
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