Stage : Early Localized Lyme Disease
Stage 1 or early localized Lyme disease occurs 128 days following a tick bite.
Some people with stage one Lyme disease do not experience any symptoms. If symptoms do occur, they may include the following:
- a skin rash that may or may not resemble a bulls-eye
- flu-like illness, including chills and a fever
- swollen lymph nodes
Recent Progress In Lyme Disease And Remaining Challenges
Lyme disease is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.
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Lyme Disease In Dogs And Other Pets
Household pets can get Lyme disease, too. Typical symptoms in animals include swollen joints and lameness, fever, and loss of appetite. Experts in the FDAs Center for Veterinary Medicine say that dogs with Lyme disease occasionally develop serious kidney disease that can be fatal.
There are ways you can reduce your pets risk for tick bites and Lyme disease. Regularly checking pets for all types of ticks, for instance, reduces the risk of infection for both pet and owner. Avoid allowing your dog to roam in tick-infested areas.
Topical, oral and/or collar products are also very important in preventing Lyme disease in dogs.
There are two basic types of Lyme disease vaccines available for dogs. Talk to your veterinarian to see if vaccination is appropriate for your dog. There is no vaccination for cats, which do not seem susceptible to Lyme disease.
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Arthropods Diseases In Humans
There are a variety of arthropods that can cause diseases in humans. These include mosquitoes, ticks, lice, and fleas. These diseases can be minor, such as a skin irritation, or they can be serious, such as Lyme disease or Rocky Mountain spotted fever.
We are unable to comprehend why arthropods and human diseases are not the same. The best source for etymology is the Arthropods Dictionary. The arthropod cuticle contains many different features in Cutler B. Arthropods. Schmidt-Nielsen The strength of a skeleton and a bone. How many species of arthropods there are in total? Erwins estimate has been revised downward. A Gubler DJ is a great DJ.
Its a disease that spreads from mosquitoes to humans. Tech off int et pharmacist In this paper, the sections are as follows: 28: 583-8. The Division of Vector-Borne Diseases , the National Center for Emerging and Zoonotic Infectious Diseases , and the Centers for Disease Control and Prevention all work on errlichiosis. According to CBS News online, the Centers for Disease Control and Prevention is underreporting Lyme disease by a significant amount. According to a CDC news release, lyme disease is more common than previously thought. Its still alive. The New York Times reports that ancient DNA evidence supports a much earlier time period than previously thought for plague.
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Disclaimer: The above material is provided for information purposes only. The material is not nor should be considered, or used as a substitute for, medical advice, diagnosis, or treatment, nor does it necessarily represent endorsement by or an official position of Global Lyme Alliance, Inc. or any of its directors, officers, advisors or volunteers. Advice on the testing, treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patients medical history. Global Lyme Alliance, Inc. makes no warranties of any kind regarding this Website, including as to the accuracy, completeness, currency or reliability of any information contained herein, and all such warranties are expressly disclaimed.
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Late Or Chronic Lyme Disease Treatment
Experts agree that the earlier you are treated the better, since early treatment is often successful. Unfortunately, a substantial portion of patients treated with short-term antibiotics continue to have significant symptoms. The quality of life of patients with chronic Lyme disease is similar to that of patients with congestive heart failure. Doctors dont agree about the cause of these ongoing symptoms. The primary cause of this debate is flawed diagnostic testing. There is currently no test that can determine whether a patient has active infection or whether the infection has been eradicated by treatment.
The IDSA thinks Lyme disease symptoms after treatment represent a possibly autoimmune, post-Lyme syndrome that is not responsive to antibiotics. The IDSA essentially regards Lyme disease as an acute infection like strep throat that can be treated with a short course of antibiotics. The IDSA guidelines are now eight years old and do not reflect recent science.
ILADS physicians believe that ongoing symptoms probably reflect active infection, which should be treated until the symptoms have resolved. These physicians use treatment approaches employed for persistent infections like tuberculosis, including a combination of drugs and longer treatment durations. The ILADS guidelines have just recently been updated using a rigorous review of the medical literature.
Azlocillin An Amazing Compound
The study team first tested to see whether different doses of the drugs could kill drug-tolerant borrelia bacteria grown on laboratory plates better than a standard Lyme disease antibiotic .
They carried out each experiment three times in triplicate . The team tested the drugs on different ages of bacteria, colonies that were 3 days old and growing rapidly, and colonies that were 710 days old and had reached a growth plateau.
At high concentrations, both drugs could kill all the drug-resistant borrelia cells and outperformed the standard Lyme disease antibiotic. When the study team tested the drugs at lower doses, azlocillin outperformed the standard antibiotic and cefotaxime, which left 20% of the drug-resistant cells alive.
The researchers tested the drugs in a small number of laboratory-bred mice that they infected with the bacteria. They treated the mice at different stages of the disease at 7, 14, and 21 days after infection.
They gave each mouse a daily dose of either azlocillin, cefotaxime, or the standard treatment for Lyme disease for 5 days. They cultured the mouse organs and checked for live bacteria using microscopy and genetic testing 2 days after the last dose.
The researchers found that both the standard treatment and azlocillin completely cleared the infection in the early stages of the disease, while cefotaxime did not.
We have been screening potential drugs for 6 years, Venkata Raveendra Pothineni, Ph.D., the lead study author says.
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Lyme Disease Antibiotic Treatment Research
For early Lyme disease, a short course of oral antibiotics, such as doxycycline or amoxicillin, cures the majority of cases. In more complicated cases, Lyme disease can usually be successfully treated with three to four weeks of antibiotic therapy.
After being treated for Lyme disease, a minority of patients may still report non-specific symptoms, including persistent pain, joint and muscle aches, fatigue, impaired cognitive function, or unexplained numbness. These patients often show no evidence of active infection and may be diagnosed with post-treatment Lyme disease syndrome .
Multiple clinical trials, funded by NIH and others, have shown no benefit to additional IV antibiotic treatment in patients with Lyme disease, although the interpretation of those results have been challenged by some.
Lyme Disease Treatment In Humans
In this blog, we will look at treating Lyme Disease. You will learn:
- What the standard treatment for Lyme Disease is and how successful it typically is
- What are the possible approaches that we can use to treat symptoms of Lyme Disease
- How Functional Medicine can help to successfully treat Lyme Disease
Do you suffer from Lyme Disease and do you know how to treat it? Has your treatment for Lyme Disease been successful? If you are struggling with these issues, then this blog is for you. Please read on for the details!
** Please note: If you want the longer, more detailed version of this article, then please click here **
What is Lyme Disease?
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What Do You Do If There’s A Tick Under Your Skin
Use a pair of fine-tipped tweezers to remove it as soon as possible. Pull upward with steady pressure. If parts of the tick are still in your skin, try to get those with the tweezers, too. After everything is out, clean the bite area with rubbing alcohol or soap and water.
You probably wonât get infected if you remove the tick within 36 to 48 hours.
How do you throw away a tick?
Put it in soapy water or alcohol, stick it to a piece of tape, or flush it down the toilet.
Other Surprising Lyme Disease Symptoms
So many people are walking around with inexplicable health conditions and baffling symptoms.
Conventional doctors are often perplexed by the striking range of symptoms, leading to severe misdiagnosis. Patients are often brushed off as hypochondriacs or having mental illnesses neither of which leads to a resolution.
The tsunami of symptoms is not some strange mystery illness. Its often simply Lyme Disease that can manifest as:
- Flu-like symptoms Fever, chills, fatigue, body aches, and a headache may accompany the rash.
- Joint pain If the infection is not treated, bouts of severe joint pain and swelling, weakness and arthritis may occur, particularly in the knees.
- Unexplained SymptomsBrain Fog, malaise, fatigue, dizziness, aches and pains, headaches, anxiety, mood swings, depression, abdominal pains, nausea, diarrhea, sleep disturbances, stiff neck
- Neurological problems In some cases, untreated infection resulting from Lyme disease may result in inflammation of the membranes surrounding the brain , temporary paralysis of one side of the face and weakness, numbness, tingling, shooting pains or burning in different parts of the body or limbs.
Many patients are startled to discover their poor health is the result of having Lyme Disease.
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Scientists Find Promising New Treatment For Lyme Disease
A new study gives hope that an effective treatment for Lyme disease may be available in the future. The new treatment involves the drugs cefotaxime and azlocillin.
The new paper appears in the Nature journal Scientific Reports .
Lyme disease affects nearly 300,000 people a year in the United States and around 230,000 people a year in Europe, according to an article in the Journal of Public Health .
Bacteria belonging to the group Borrelia burgdorferi cause Lyme disease. Most people develop it after being bitten by a tick that carries the bacteria.
Approximately 6080% of people with Lyme disease develop a circular red skin rash called erythema migrans around the infected tick bite, and some also develop flu-like symptoms.
Most people develop the rash within 4 weeks of being bitten, but it can appear up to 3 months afterward.
of people with the disease later develop symptoms of fatigue, pain in their muscles, joints or nerves, and cognitive impairment.
These symptoms can continue for months or even years after their initial infection.
Researchers have suggested that this may because of drug-tolerant persisters, a group of bacterial cells that survive the initial dose of antibiotics.
Others believe its an immune disorder caused by bacteria during the first exposure, which causes a perpetual inflammation condition. Whatever the cause, the pain for patients is still very real.
When To See A Healthcare Provider
Prompt treatment for Lyme disease reduces the risk of lingering symptoms and complications. If youve already been treated with antibiotics but continue to experience issues, talk to your healthcare provider to determine if additional treatment is necessary. Patience and proactive communication with your healthcare professional will help you get back to your usual state of health.
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How To Remove A Tick
A tick must remain attached to the skin for at least 36 hours to spread Lyme disease. The best way of preventing Lyme disease is to remove a tick as soon as possible.
The blacklegged tick that spreads disease-causing bacteria resembles a tiny spider. Young ticks are around the size of a poppy seed, while adult ticks are around the size of a sesame seed. Ticks of all ages are reddish-brown.
Below are some steps for tick removal.
- Step 1: Use fine-tipped tweezers to gently grasp the tick near its head or mouth. Avoid squeezing the tick.
- Step 2: Using the tweezers, pull the tick carefully and steadily away from the skin. Avoid yanking or twisting the tick, as this could cause its mouthparts to remain in the skin.
- Step 3: After removing the tick, dispose of it by putting it in some alcohol or flushing it down the toilet.
- Step 4: Apply antiseptic to the tick bite.
Healthy Vs Weak Cells
How all this plays out is a function of the health of cells as much as the aggressiveness of the bacteria: Cells that are weak from being chronically stressed are more vulnerable to invasion by bacteria.
A healthy person with healthy cells who is bitten by a tick may not have much in the way of acute symptoms and may never develop chronic symptoms. It doesnt mean, however, that the bacteria have been eradicated from the body. They can stay dormant in tissues for a lifetime.
All it takes is a shift in the health of cells for dormant bacteria to surface and invade more cells. The immune system scrambles to keep a lid on things as bacteria erupt and infect other cells. Dead cells break apart and create debris. Macrophages secrete acid and free radicals to break down debris. Reinforcements are called in. More acid. More free radicals. More collateral damage. More debris. Flow of nutrients and oxygen is obstructed and cells are weakened even further.
The invasion intensifies as more cells are infected. Along with inflicting injury to cells in tissues, bacteria infect and kill WBCs. In addition, bacteria throw the immune system off balance by disrupting the cytokines the immune system uses to coordinate the resistance. As the process spirals out of control, the immune system loses the capacity to keep microbes in check.
Before long, tissues throughout the body start to look like a war zone. Cells suffer. Symptoms result. It becomes a never-ending cycle of misery.
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Where Are Ticks Found
Ticks are found throughout the UK and in other parts of Europe and North America. There are a high number of ticks in the Scottish Highlands.
They can be found in any areas with deep or overgrown plants where they have access to animals to feed on.
Theyâre common in woodland and moorland areas, but can also be found in gardens or parks.
What Are The Stages Of Lyme Infection
There are three stages:
- Early localized Lyme: Flu-like symptoms like fever, chills, headache, swollen lymph nodes, sore throat, and a rash that looks like a bull’s-eye or is round and red and at least 2 inches long
- Early disseminated Lyme: Flu-like symptoms like pain, weakness, or numbness in your arms and legs, changes in your vision, heart palpitations and chest pain, a rash , and a type of facial paralysis known as Bellâs palsy
- Late disseminated Lyme: This can happen weeks, months, or years after the tick bite. Symptoms might include arthritis, severe fatigue and headaches, dizziness, trouble sleeping, and confusion.
About 10% of people treated for Lyme infection donât shake the disease. They may go on to have three core symptoms: joint or muscle pain, fatigue, and short-term memory loss or confusion. This is called post-treatment Lyme disease syndrome. It can be hard to diagnose because it has the same symptoms as other diseases. Plus, there isn’t a blood test to confirm it.
Experts arenât sure why Lyme symptoms donât always go away. One theory is that your body keeps fighting the infection even after the bacteria are gone, like an autoimmune disorder.
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Later Symptoms Of Lyme Disease
More serious symptoms may develop if Lyme disease is left untreated or is not treated early. These can include:
- pain and swelling in the joints
- nerve problems such as numbness or pain in your limbs
- memory problems
- difficulty concentrating
Some of these problems will get better slowly with treatment. But they can persist if treatment is started late.
A few people with Lyme disease go on to develop long-term symptoms similar to those of fibromyalgia or chronic fatigue syndrome. This is known as post-infectious Lyme disease. It’s not clear exactly why this happens. It’s likely to be related to overactivity of your immune system rather than continued infection.
Can Lyme Disease Completely Be Cured
Taking oral antibiotics typically cures Lyme disease after two to four weeks. You may need to get antibiotics through the vein for four more weeks. However, theres no reason to think that Lyme disease stays in you forever after treatment.
A note from Cleveland Clinic
If youre going to spend time in an area that might have ticks, take measures to avoid being bitten. This includes wearing long-sleeved shirts and pants to make it harder for ticks to bite. If you feel sick after being in an area that probably has ticks, make an appointment with your healthcare provider. If your provider prescribes antibiotics, make sure you take all of them as instructed.
Last reviewed by a Cleveland Clinic medical professional on 08/16/2022.
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