What Is The Treatment For Lyme Disease
The first-line standard of care treatment for adults with Lyme disease is doxycycline, a tetracycline antibiotic. Other antibiotics that have activity against borrelia include the penicillin-like antibiotic, amoxicillin, and the second generation cephalosporin, Ceftin. The mainstay of treatment is with oral antibiotics, but intravenous antibiotics are sometimes indicated for more difficult to treat cases of neurologic-Lyme disease, such as meningitis, and cases of late Lyme arthritis.
Ongoing Symptoms Of Lyme Disease
A few people who are diagnosed and treated for Lyme disease continue to have symptoms, like tiredness, aches and loss of energy, that can last for years.
It’s not clear why this happens to some people and not others. This means there’s also no agreed treatment.
Speak to a doctor if your symptoms come back, or do not improve, after treatment with antibiotics.
The doctor may be able to offer you further support if needed, such as:
- referral for a care needs assessment
- telling your employer, school or higher education institution that you require a gradual return to activities
- communicating with children and families’ social care
Page last reviewed: 05 July 2021 Next review due: 05 July 2024
What Are Possible Complications Of Lyme Disease In A Child
Some children may develop post-Lyme disease syndrome . This means that some symptoms last longer than 6 months. Symptoms can include:
- Ongoing muscle and nerve pain
- Problems with memory
PLDS does not respond to antibiotics. That’s because there isn’t an active infection anymore. Treatment is aimed at helping to control the symptoms.
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Tick Bite Eyed In Toddler’s Death
The only way to protect yourself against the disease is to avoid being bitten by a tick and when in infested areas, take the same precautions as with Lyme.
Try to make yourself as unappealing and inhospitable to ticks as possible,” said Morse. “Wear long sleeves and long pants with the cuffs tucked into your socks so nothing can crawl up your leg. Use a repellent with DEET.
Armstrong suggests taking a shower once you come back inside and then having someone inspect all the nooks and crannies of your body where ticks like to hide, like your scalp, ears, groin and behind the knees.
Pets who spend time may bring ticks into the house, so should be give appropriate repellents.
The standard therapy for anaplasmosis is doxycycline. Since severe symptoms are more likely to occur if treatment is delayed, doctors generally dont wait for test results to come back before prescribing the antibiotic, Armstrong said.
Months after being diagnosed and treated for the disease, Diamond’s symptoms persist.
I still have issues with my joints and hands and shoulders, he said. And Im still extremely tired. I sleep almost every afternoon.
This updated story was originally published in October, 2017
How Long Does Lyme Disease Last
Lyme disease symptoms can begin anywhere from three to 30 days after transmission of the infection from a tick. If treated early on with antibiotics, most people feel better within a few weeks, says Dr. Zemel.
According to the CDC, its not uncommon for people to experience lingering symptoms like fatigue and joint or muscle pain for a few weeks or months after treatment. Additional antibiotics wont help these symptoms, however, and most people improve on their own over time.
In a small percentage of cases, people continue to experience symptoms for more than six months after their recommended course of antibiotics is completed. This is sometimes referred to as chronic Lyme diseasebut that name is misleading, says Dr. Kuritzkes, because there is no evidence that the bacteria that causes Lyme disease is still present in the body. Instead, the CDC refers to this condition as post-treatment Lyme disease syndrome .
As with many other kinds of infectious diseases, some people are left with some debilitating symptoms that dont go away, says Dr. Kuritzkes. I like to compare it to polio: Some people who had polio are left paralyzed, but that doesnt mean they have chronic polio they have permanent damage from the infection, even after its gone away.
Its possible that Lyme infection leads to some damage that we dont fully understand yet, Dr. Kuritzkes adds. But we do know that long-term or repeated courses of antibiotics have no benefit in these cases.
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Who Gets Lyme Disease
Anyone bitten by an infected deer tick can get Lyme disease. Most U.S. cases of Lyme disease happen in Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia, and Wisconsin. But Lyme disease is found in other parts of the U.S., Europe, Asia, and Australia too.
How Do I Remove A Tick
You should know how to remove a tick just in case one lands on you or a friend. To be safe, remove the tick as soon as possible.
If you find a tick:
- Use tweezers to grasp the tick firmly at its head or mouth, next to your skin.
- Pull firmly and steadily on the tick until it lets go of the skin. If part of the tick stays in your skin, don’t worry. It will eventually come out. But call your doctor if you notice any irritation in the area or symptoms of Lyme disease.
- Swab the bite site with alcohol.
Note: Don’t use petroleum jelly or a lit match to kill a tick. They won’t get the tick off your skin quickly enough, and may just cause it to burrow deeper into your skin.
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Importance Of The Study
The LymeProspect study shows that some Lyme patients remain limited in their physical and social functioning after treatment with antibiotics. In addition, fatigue, pain and concentration problems are reported more often by people with Lyme disease than by people without this disease: about 27% of the Lyme patients and 21% to 23% of the people without this disease. Also, the complaints of the Lyme patients were more severe. It is likely that such long-term symptoms may be the result of Lyme disease, but only in a small but substantial proportion of patients. It is important to acknowledge persistent symptoms and to obtain a better understanding of the causes of these symptoms. This can help prevent complaints and improve treatment.
What Are The Signs & Symptoms Of Lyme Disease
Lyme disease can affect different body systems, such as the nervous system, joints, skin, and heart. The symptoms of Lyme disease are often described as happening in three stages. Not everyone with Lyme has all of these, though:
The rash sometimes has a “bull’s-eye” appearance, with a central red spot surrounded by clear skin that is ringed by an expanding red rash. It also can appear as an growing ring of solid redness. It’s usually flat and painless, but sometimes can be warm to the touch, itchy, scaly, burning, or prickling. The rash may look and feel very different from one person to the next. It can be harder to see on people with darker skin tones, where it can look like a bruise. It gets bigger for a few days to weeks, then goes away on its own. A person also may have flu-like symptoms such as fever, tiredness, headache, and muscle aches.
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Has Niaid Looked At Whether Infection Persists After Antibiotic Therapy
Several recent studies suggest that B. burgdorferi may persist in animals after antibiotic therapy. In one study, NIAID-supported scientists found that remnants of B. burgdorferi remained in mice after antibiotic treatment. Another team of NIAID-supported investigators found that intact B. burgdorferi persist in nonhuman primates after antibiotic treatment. It was not possible to culture these bacteria and it is not clear whether they are infectious. More recent work by Hodzic et al. replicated the earlier finding of persisting DNA but non-cultivatable B. burgdorferi after antibiotic treatment using a mouse model. In 2017, scientists at the Tulane National Primate Research Centers, funded in part by an NIH research resources grant, reported evidence of persistent and metabolically active B. burgdorferi after antibiotic treatment in rhesus macaques.
In a first-of-its-kind study for Lyme disease, NIAID-supported researchers have used live, disease-free ticks to see if Lyme disease bacteria can be detected in people who continue to experience symptoms such as fatigue or arthritis after completing antibiotic therapy). This study remains underway.
The Chance Of Getting Lyme Disease
Not all ticks in England carry the bacteria that causes Lyme disease.
But it’s still important to be aware of ticks and to safely remove them as soon as possible, just in case.
Ticks that may cause Lyme disease are found all over the UK, but high-risk places include grassy and wooded areas in southern and northern England and the Scottish Highlands.
Ticks are tiny spider-like creatures that live in woods, areas with long grass, and sometimes in urban parks and gardens. They’re found all over the UK.
Ticks do not jump or fly. They attach to the skin of animals or humans that brush past them.
Once a tick bites into the skin, it feeds on blood for a few days before dropping off.
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What Happens At Your Appointment
The GP will ask about your symptoms and consider any rash or recent tick bites you know about.
Lyme disease can be difficult to diagnose. It has similar symptoms to other conditions and there’s not always an obvious rash.
2 types of blood test are available to help confirm or rule out Lyme disease. But these tests are not always accurate in the early stages of the disease.
You may need to be retested if you still have Lyme disease symptoms after a negative result.
How Is Lyme Disease Diagnosed And Treated
Lyme disease is usually diagnosed when a person develops a bull’s-eye rash, flu-like symptoms , or both. These symptoms usually start a few days or weeks after the person is bitten by an infected tick.
A two-step blood test can verify the presence of Lyme disease antibodies, although it does take a few weeks for those antibodies to develop. And despite what some physicians and advocacy groups claim, a blood test is the only way Lyme disease can be confirmed, Larry Zemel, MD, head of rheumatology at Connecticut Childrens Medical Center, tells Health. Some doctors say they can diagnose Lyme even when patients test negative repeatedly, but that has not been borne out by any scientific study, he says.
When people are diagnosed with Lyme disease in its early stages, a 10- to 20-day course of oral antibioticsusually with a drug called doxycyclinewill clear the infection and help them feel better fairly quickly. This cures the vast majority of people, and they have a 100% recovery with no lasting effects, says Dr. Zemel.
If Lyme disease isnt diagnosed right away, it can cause more serious symptoms like arthritis and memory problems. These people may need a full month of oral antibiotics, says Dr. Zemel. About 20% of these patients will need IV antibiotics , and they may also need other medications to treat symptoms like pain and muscle stiffness.
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How Is Lyme Disease Treated
For early Lyme disease, a short course of oral antibiotics such as doxycycline or amoxicillin is curative in the majority of the cases. In more complicated cases, Lyme disease can usually be successfully treated with three to four weeks of antibiotic therapy.
In patients who have non-specific symptoms after being treated for Lyme disease and who have no evidence of active infection , studies have shown that more antibiotic therapy is not helpful and can be dangerous.
What Are Some Long
Possible long-term effects of Lyme disease include facial palsy, neuropathy, impaired memory, heart rhythm irregularities and chronic inflammation of the joints, particularly the knees, says Mayo Clinic. These effects are unlikely to occur if the disease is treated promptly.
Lyme disease is a bacterial infection spread by deer ticks when they bite humans, Mayo Clinic explains. Generally, the ticks must remain attached for 36 to 48 hours in order to transmit Lyme disease. The more immediate symptoms of Lyme disease include chills, fever, body aches, fatigue and headache. A rash shaped like a bulls eye around the tick bite, which is a hallmark of the disease, develops a couple of days following the bite. Inflammation of the liver or the eye can arise several weeks after the initial infection. People who suspect theyve been bitten should see a doctor even if initial symptoms go away on their own, as Lyme disease can sometimes progress asymptotically months or years after the infection.
The standard treatment for early-stage Lyme disease consists of oral antibiotics, states Mayo Clinic. When the disease has progressed to attack the nervous system, intravenous antibiotics may be needed. While these are effective at eliminating the disease organisms, the symptoms they cause may persist for some time. Even in the case that curing the disease is relatively simple, a few people experience lingering muscle aches and fatigue.
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How To Prevent Post
While you may not be able to prevent post-treatment Lyme disease syndrome, you can take precautions to prevent coming into direct contact with infected ticks. The following practices can reduce your likelihood of getting Lyme disease and developing persistent symptoms.
If a tick bites you, contact your doctor. You should be observed for 30 days for signs of Lyme disease. You should also learn the signs of early Lyme disease and seek prompt treatment if you think youre infected. Early antibiotic intervention may reduce your risk of developing chronic symptoms.
The signs of early Lyme disease can occur from 3 to 30 days after a bite from an infected tick. Look for:
- a red, expanding bulls-eye rash at the site of the tick bite
Who’s At Risk And Where Are Ticks Found
The risk of getting Lyme disease is higher:
- for people who spend time in woodland or moorland areas
- from March to October because more people take part in outdoor activities
Ticks are found throughout the UK and in other parts of Europe and North America. There are a high number of ticks in the Scottish Highlands.
It’s thought only a small proportion of ticks carry the bacteria that cause Lyme disease. Being bitten doesn’t mean you’ll definitely be infected. However, it’s important to be aware of the risk and speak to a GP if you start to feel unwell.
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Has Niaid Looked At The Potential Benefits Of Long
Yes. NIAID has funded three placebo-controlled clinical trials on the efficacy of prolonged antibiotic therapy for treating PTLDS. The published results were subjected to rigorous statistical, editorial, and scientific peer review.
These trials were designed to ensure that several key parameters were addressed:
- The susceptibility of B.burgdorferi to the antibiotics used
- The ability of the antibiotics to both cross the blood-brain barrier and access the central nervous system and to persist at effective levels throughout the course of therapy
- The ability of the antibiotics to kill bacteria living both outside and inside mammalian cells
- The safety and welfare of patients enrolled in the trials
The first clinical trial, which included two multicenter studies, provided no evidence that extended antibiotic treatment is beneficial. In those studies, physicians examined long-term antibiotic therapy in patients with a well-documented history of previous Lyme disease but who reported persistent pain, fatigue, impaired cognitive function, or unexplained numbness. Those symptoms are common among people reporting PTLDS. Patients were treated with 30 days of an intravenous antibiotic followed by 60 days of an oral antibiotic.
In 2016, a clinical trial conducted in the Netherlands also concluded that in patients with persistent symptoms attributed to Lyme disease, longer term treatment with antibiotics did not provide additional benefits compared with shorter term regimens.
Symptoms Of Post Treatment Lyme Disease
- Include severe fatigue, musculoskeletal pain, & cognitive problems
- Can significantly impact patients health and quality of life
- Can be debilitating and prolonged
Our research indicates the chronic symptom burden related to PTLD is significant. Although often invisible to others, the negative impact on quality of life and daily functioning is substantial for PTLD sufferers.
The chronic symptom burden related to Lyme disease is considerable, as shown on the left side of the graph above, and statistically significantly greater than the aches and pains of daily living experienced by the control group, on the right.
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Current Challenges And Future Priorities
Patients with PTLD represent a substantial burden to the United States health care system. In a large, health insurance claims analysis of 47 million members, estimated total direct medical costs from Lyme disease were between $712 million and $1.3 billion per year, with a significant portion of these specifically due to PTLD-related costs . The same study found that the adjusted odds of any PTLD-related symptom diagnosis following Lyme disease was 4.77 higher than age-, sex-, enrollment year-, region- and payer type-matched controls without Lyme disease, and that those patients with Lyme disease who went on to have at least one PTLD symptom had over twice the average total health care costs as those who did not . These cost estimates do not reflect additional indirect, non-medical, and lost productivity costs to patients, which may be substantial in a population with a chronic and significant illness impact on quality of life . Novel preventative approaches to reduce incidence of new Lyme disease cases, as well as physician and community educational interventions to increase awareness and reduce diagnostic delays and misdiagnosis, are needed to reduce costs and improve patient outcomes.