Tuesday, May 24, 2022

What Is The Best Treatment For Lyme Disease

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The Truth About Antibiotic Treatments

What is the Best Treatment for Lyme Carditis?

Until recently, many doctors in Canada tended to prescribe only one round of antibiotics, irrespective of the stage of infection. However, current research suggests that a single course of antibiotics is often insufficient for treating Lyme disease, especially if the infection has been untreated for several months.

Considerations While On Lyme Treatment

Antibiotics can wipe out beneficial intestinal flora, leading to a wide variety of additional health problems. It is important to take probiotics while on antibiotics to maintain a healthy balance of gut bacteria. Furthermore, antibiotics may interact with other drugs, supplements or food. The National Institutes of Healths MedLinePlus website gives information about drug interactions.

What Is The Outlook For Someone With Lyme Disease

Most of the people who get Lyme disease and treated early will be fine.

Post-Lyme Syndrome

Even after proper treatment, some patients may experience lingering fatigue, achiness or headaches. This does not signify ongoing infection and will not respond to additional antibiotics. The majority of people in this group will have symptoms resolve over the next 1-6 months.

Chronic Lyme Syndrome

Chronic Lyme syndrome is a term used by some that includes the symptoms of Post-Lyme syndrome outlined above. This is a controversial topic with no accepted etiology and no proven cause or association.

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Azlocillin Comes Out On Top

The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.

Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.

Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.

Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD senior research scientist Mohammed Inayathullah, PhD and intern Mohamed Sohail Ahmed.

A researcher at Loyola College in India also contributed to the work.

The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.

  • Tracie White

Chronic Lyme Dos And Donts

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Chronic Lyme disease is an ongoing Borrelia burgdorferi infection that can involve any body system or tissue. The infection produces a wide range of symptoms and signs, which can be debilitating for some patients. Common symptoms include severe fatigue, migratory musculoskeletal pain, headaches, and impaired memory. Unfortunately, chronic Lyme disease is complex and often misunderstood, which means that many patients will struggle to obtain the care they need to regain their health. Every patient concerned about Lyme disease and tick-borne illness should know the following.

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Video Answer: Lyme Disease: Diagnosis And Treatment For People And Pets

In the past, it may have been difficult for dogs to survive Lyme disease due to the inability to diagnose the disease.

If your dog does contract Lyme disease, however, they are likely to exhibit the symptoms listed above.

These symptoms are caused by the Borrelia burgdorferi bacterium in the bite of an infected tick.

Lyme disease in dogs is curable, however, this may depend on each case and at what stage of the disease the dog receives treatment during.

Most dogs that are diagnosed with Lyme disease will be given a prescription of doxycycline, which is the most common type of antibiotic used to treat this condition.

What Is The Treatment For Lyme Disease

The first-line standard of care treatment for adults with Lyme disease is doxycycline, a tetracycline antibiotic. Other antibiotics that have activity against borrelia include the penicillin-like antibiotic, amoxicillin, and the second generation cephalosporin, Ceftin. The mainstay of treatment is with oral antibiotics, but intravenous antibiotics are sometimes indicated for more difficult to treat cases of neurologic-Lyme disease, such as meningitis, and cases of late Lyme arthritis.

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Hunting For Alternative Drug

Frustrated by the lack of treatment options for Lyme disease patients with lingering symptoms, Rajadas and his team began hunting for a better alternative in 2011. In 2016, they published a study in Drug Design, Development and Therapy that listed 20 chemical compounds, from about 4,000, that were most effective at killing the infection in mice. All 20 had been approved by the Food and Drug Administration for various uses. One, for instance, is used to treat alcohol abuse disorder.

Jayakumar Rajadas

In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it is more effective in killing B. burgdorferi and causes fewer side effects. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease Control and Prevention. It can affect various organs, including the brain, skin, heart, joints and nervous system, and cause heart problems and arthritis if untreated. Symptoms include fever, headaches, chills, and muscle and joint pain.

Traditional antibiotics, such as doxycycline, are effective as an early course of treatment for the infection in the majority of patients, but it remains unclear why these drugs fail to treat 10% to 20% of patients, Rajadas said.

What Is The Best Antibiotic For Lyme Disease

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The best anitbiotic for Lyme disease is Doxycycline. Doxycycline was the first to be found, and it works on both ticks and Lymecycline in ring form. Doxycycline combined with amoxicillin has proved to provide an even better results. The only downside of doxycyclines is that people under age 35 have higher chances of developing acne. And while others are being studied, so far there has not been a magic bullet against the bacterial family of Borrelia burgdorferi, which causes Lyme disease after an incubation period ranging from 3 days to months before any associated symptoms are experienced . It can take anywhere from 2-6 weeks for antibiotics or other treatments to kill all of the bacteria.

Doxycycline is an antibiotic used to treat infections such as Lyme disease and other tick-borne diseases, acne , rosacea, chlamydia , and others.

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Questions To Ask Your Veterinarian

If your dog has a positive Lyme test but no symptoms of the disease or protein in the urine, ask your veterinarian why he or she is recommending treatment. Experts currently recommend against antibiotic therapy under these circumstances because the dogs immune system is holding the bacteria in check and antibiotics are unable to eliminate the infection.

Dogs who have contracted Lyme disease do not develop prolonged, protective immunity and can be reinfected at a later date. Talk to your veterinarian about how best to prevent future infections. Options include measures to prevent the ticks that carry Lyme disease from biting your dog and Lyme vaccination.

Why Was This Study Needed

Lyme disease affects around 2,000 to 3,000 people a year in England and Wales. Although still uncommon, cases have risen in recent years, with warmer winters likely to be a contributing factor. It is caused by an infection with the bacteria Borrelia burgdorferi, spread through infected ticks.

Early symptoms are usually mild. Many people experience a rash that starts around the bite area and may have flu-like symptoms. If left untreated, more serious complications can occur such as nerve pain and heart problems.

Antibiotics are the standard treatment, with doxycycline being the first line antibiotic recommended by NICE. Whilst it is clear they work, the evidence supporting the choice of antibiotic agent is not conclusive. Additionally, the researchers wanted to see if the data pointed to a best treatment regimen and whether dose and treatment length are important.

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Who Gets Lyme Disease

Anyone bitten by an infected deer tick can get Lyme disease. Most U.S. cases of Lyme disease happen in Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia, and Wisconsin. But Lyme disease is found in other parts of the U.S., Europe, Asia, and Australia too.

How To Spot And Remove Ticks

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If you find a tick attached to your body, carefully pull it out using tweezers. Dont squeeze too hard because this could hurt the animal. If theres any doubt about whether the tick has been removed completely, leave it where it was until someone else removes it.

You should check yourself regularly for ticks while walking through woodland, especially at dusk and dawn. Youll need to keep looking down so you dont miss any ticks.

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Two Standards Of Care For Lyme Disease Treatment

There is significant controversy in science, medicine, and public policy regarding Lyme disease. Two medical societies hold widely divergent views on the best approach to diagnosing and treating Lyme disease. The conflict makes it difficult for patients to be properly diagnosed and receive treatment.

One medical society, the Infectious Diseases Society of America , regards Lyme disease as hard to catch and easy to cure with a short course of antibiotics. IDSA claims that spirochetal infection cannot persist in the body after a short course of antibiotics. The group also denies the existence of chronic Lyme disease.

In contrast, the International Lyme and Associated Diseases Society , regards Lyme disease as often difficult to diagnose and treat, resulting in persistent infection in many patients. ILADS recommends individualized treatment based on the severity of symptoms, the presence of tick-borne coinfections and patient response to treatment.

LDo believes that patients and their doctors should make Lyme disease treatment decisions together. This requires that patients be given sufficient information about the risks and benefits of different treatment options. Then, patient and health care provider can collaborate to reach an informed decision, based on the patients circumstances, beliefs and preferences.

Has Niaid Looked At The Potential Benefits Of Long

Yes. NIAID has funded three placebo-controlled clinical trials on the efficacy of prolonged antibiotic therapy for treating PTLDS. The published results were subjected to rigorous statistical, editorial, and scientific peer review.

These trials were designed to ensure that several key parameters were addressed:

  • The susceptibility of B.burgdorferi to the antibiotics used
  • The ability of the antibiotics to both cross the blood-brain barrier and access the central nervous system and to persist at effective levels throughout the course of therapy
  • The ability of the antibiotics to kill bacteria living both outside and inside mammalian cells
  • The safety and welfare of patients enrolled in the trials

The first clinical trial, which included two multicenter studies, provided no evidence that extended antibiotic treatment is beneficial. In those studies, physicians examined long-term antibiotic therapy in patients with a well-documented history of previous Lyme disease but who reported persistent pain, fatigue, impaired cognitive function, or unexplained numbness. Those symptoms are common among people reporting PTLDS. Patients were treated with 30 days of an intravenous antibiotic followed by 60 days of an oral antibiotic.

In 2016, a clinical trial conducted in the Netherlands also concluded that in patients with persistent symptoms attributed to Lyme disease, longer term treatment with antibiotics did not provide additional benefits compared with shorter term regimens.

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What Do I Do If I Find A Tick On My Skin

Dont panic. Use fine-tipped tweezers to grasp the tick as close to the skins surface as possible. Pull up with steady, even pressure. Be careful not to squeeze or twist the tick body. Sometimes parts of the tick remain in the skin. You can leave them alone or carefully remove them the same way you would a splinter. Do not use heat , petroleum jelly, or other methods to try to make the tick back out on its own. These methods are not effective.

Wash the area where the tick was attached thoroughly with soap and water. Keep an eye on the area for a few weeks and note any changes. Call your doctor if you develop a rash around the area where the tick was attached. Be sure to tell your doctor that you were bitten by a tick and when it happened.

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Symptoms Of Lyme Disease

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People with Lyme disease may react to it differently, and the symptoms can vary in severity.

Although Lyme disease is commonly divided into three stages early localized, early disseminated, and late disseminated symptoms can overlap. Some people will also present in a later stage of disease without having symptoms of earlier disease.

These are some of the more common symptoms of Lyme disease:

  • a flat, circular rash that looks like a red oval or bulls-eye anywhere on your body
  • other flu-like symptoms

These symptoms may occur soon after the infection, or months or years later.

Your child may have Lyme disease and not have the bulls-eye rash. According to an early study, results showed roughly 89 percent of children had a rash.

Lyme disease is best treated in the early stages. Treatment for early localized disease is a simple 10- to 14-day course of oral antibiotics to eliminate the infection.

Medications used to treat Lyme disease include:

  • doxycycline, amoxicillin, or cefuroxime, which are first-line treatments in adults and children
  • cefuroxime and amoxicillin, which are used to treat women who are nursing or breastfeeding

Intravenous antibiotics are used for some forms of Lyme disease, including those with cardiac or central nervous system involvement.

After improvement and to finish the course of treatment, healthcare providers will typically switch to an oral regimen. The complete course of treatment usually takes 1428 days.

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What To Expect From A General Practitioner In Australia

GPs are not allowed to test for Lyme. And most doctors in Australia will not refer patients for testing for Lyme unless the patient has travelled to a Lyme endemic country. This is because the Federal Government will not concede that Lyme disease can be contracted within Australia.

The reality for Australian patients presenting with Lyme symptoms, is to be told by their GP we do not have Lyme in this country. Unfortunately, Australian doctors are trained to believe that the Lyme bacteria Borrelia has not been found here.

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If a patient raises the possibility of Lyme disease, there is a high likelihood of condescension, disbelief and suggestions that its all in your head from medical staff. However, if the doctor suspects a recognised tick-borne illness, or the patient has travelled, the patient may be referred to an infectious disease specialist.

Most doctors are not Lyme-literate. They have little training in, or knowledge of Lyme disease and are required to follow the Governments official tick-borne illness guideline, Debilitating Symptom Complex Attributable to Ticks Clinical Pathway. Tragically, this guideline leaves patients who contracted Lyme within Australia with symptom management as their only treatment option within the mainstream medical system.

Stage : Early Disseminated Lyme Disease

Early disseminated Lyme disease occurs several weeks to months after the tick bite.

Youll have a general feeling of being unwell, and a rash may appear in areas other than the tick bite.

This stage of the disease is primarily characterized by evidence of systemic infection, which means infection has spread throughout the body, including to other organs.

Symptoms can include:

  • disturbances in heart rhythm, which can be caused by Lyme carditis
  • neurologic conditions, such as numbness, tingling, facial and cranial nerve palsies, and meningitis

The symptoms of stages 1 and 2 can overlap.

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Living With Lyme Disease

Most people treated in the early stages of Lyme disease make a quick and complete recovery. Some may experience symptoms for a few weeks after treatment. If you were treated for Lyme disease but you still dont feel well, call your family doctor. He or she can make sure there isnt something else wrong. They can help you find ways to ease your symptoms. Some patients have found relief with treatments typically used for chronic fatigue syndrome or fibromyalgia.

Other things you can do to help manage Lyme disease include:

  • Educate yourself.There is a lot of inaccurate information to be sorted through, especially on the internet. Ask your doctor if you have questions.
  • Track your symptoms.Keep a diary of your sleep patterns, eating habits, exercise routines, and how youre feeling. You or your doctor may be able to make connections between them.
  • Take care of yourself.Eat a healthy diet. Exercise as regularly as you can. Get plenty of rest.

Find support. It can be hard to not feel well and not know why. Some people may think your symptoms arent real. Talk to friends and family. If they cant offer support, talk with a counselor who can help you.

What Is Post Treatment Lyme Disease

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Post Treatment Lyme Disease represents a research subset of patients who remain significantly ill 6 months or more following standard antibiotic therapy for Lyme disease. PTLD is characterized by a constellation of symptoms that includes severe fatigue, musculoskeletal pain, sleep disturbance, depression, and cognitive problems such as difficulty with short-term memory, speed of thinking, or multi-tasking. In the absence of a direct diagnostic biomarker blood test, PTLD has been difficult to define by physicians, and its existence has been controversial. However, our clinical research shows that meticulous patient evaluation when used alongside appropriate diagnostic testing can reliably identify patients with a history of previously treated Lyme disease who display the typical symptom patterns of PTLD.

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