A Targeted Lyme Disease Treatment
But back to the optimism mentioned at the start of this article: During a recent study, a team under Kim Lewis at Northeastern University found that a compound called hygromycin A is completely harmless to animals and has little effect on most bacteria except so-called spirochete bacteria, named for their spiral shape. For those, it is deadly. And Borrelia burgdorferi, the pathogen that causes Lyme disease, belongs to just this group.
Hygromycin A is an antimicrobial agent found in soil. The substance was originally discovered in 1953. At the time, however, scientists dismissed it as ineffective, probably because it seemed too weak to fight normal pathogens. But Lewis considers it exceptionally effective against spirochetes.
Lewis team discovered the efficacy of hygromycin A while screening microorganisms in soil for antimicrobial compounds. We set out to find such a compound that would selectively kill Borreliella burgdorferi , placing a bet, if you will, that Mother Nature had bothered to evolve a compound to selectively take out spirochetes that live in the soils, Lewis says.
And indeed, Mother Nature has done exactly that.
The researchers have already licensed the compound to Flightpath, a biotech company specializing in Lyme disease, to conduct development studies and advance production of this treatment.
Azlocillin Comes Out On Top
The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.
Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.
Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.
Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD senior research scientist Mohammed Inayathullah, PhD and intern Mohamed Sohail Ahmed.
A researcher at Loyola College in India also contributed to the work.
The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.
What Is The History Of Lyme Disease
Interestingly, the disease only became apparent in 1975 when mothers of a group of children who lived near each other in Lyme, Conn., made researchers aware that their children had all been diagnosed with joint pain from rheumatoid arthritis. This unusual grouping of illnesses that appeared rheumatoid eventually led researchers to the identification of the bacterial cause of the childrens condition, which was then named Lyme disease in 1982.
The only vector for Lyme disease in the U.S. is the black-legged tick, or deer tick, known as Ixodes scapularis. These ticks are carriers of the Lyme disease spirochete in their stomachs Ixodes ticks may also transmit the Powassan virus. The ticks are vectors that can transmit the bacterium to humans with a tick bite. The number of cases of tick-borne illness in an area depends on the number of ticks present and how often the ticks are infected with the bacteria. In certain areas of New York, where Lyme disease is common, over half of the ticks are infected. Lyme disease has been reported most often in the northeastern United States, but it has been reported in all 50 states, as well as China, Europe, Japan, Australia, and parts of the former Soviet Union. In the United States, it is primarily contracted in the Northeast in the states from Maine to Maryland, in the Midwest in Minnesota and Wisconsin, and in the West in Oregon and Northern California. What those children actually had was Lyme arthritis.
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Brain Fog In Lyme Disease: What Is It
There are two kinds of brain fog in Lyme disease. Some people have both forms.
- Type 1 Brain Fog. The first kind is a feeling or sensation of cloudiness or fogginess of the head.
- Type 2 Brain Fog. The second type is a problem with brain function where a person cannot think. People with thinking problems usually have problems with short-term memory, confusion, poor attention, organization, word finding, or concentration.
Type 1 brain fog is caused by a buildup of cytokine inflammation chemicals and another chemical made in brain infections called quinolinic acid. It is also due to a buildup of toxins in the blood from mold or yeast overgrowth in the intestines. While the literature does not describe this type of brain fog or its treatment. I have observed great improvement in Type 1 brain fog by lowering cytokine inflammation chemicals with liposomal curcumin 500 mg 3 times a day, eliminating intestinal yeast, or removing mold toxins. See Step One: Treat Infections or Mold Toxins below for links to articles on this site regarding yeast and mold toxins. Note, fixing Type 2 brain fog also fixes Type 1 brain fog.
In this article I focus primarily on the treatment steps for Type 2 brain fog. Type 2 brain fog has three possible causes
Herbs For Lyme Disease Treatment
Herbs have been used as a medicinal treatment for thousands of years. Many people have turned to herbal remedies to help provide relief from Lyme disease when antibiotics didn’t completely help eliminate symptoms.
One research study found that a combination of doxycycline and baicalein provides additional healing benefits. According to a 2020 laboratory study, seven herbal medicines have been shown to kill B. burgdorferi in test tubes:
- Cryptolepis sanguinolenta
- Scutellaria baicalensis
Garlic has antibacterial effects and may help prevent tick bites. One study determined that people who took garlic supplements reported fewer tick bites than the placebo group. Garlic essential oil has been shown to eliminate the bacterium that causes Lyme disease.
Garlic can interact with certain medications, so speak with your healthcare provider before using it to prevent or treat Lyme disease.
Steviaa natural sweetener and sugar substitute derived from the leaves of the Stevia rebaudiana plantmay be effective in treating Lyme disease. A study published in the European Journal of Microbiology and Immunology discovered that stevia extracts are more effective in killing Lyme disease bacterium in the lab than the standard antibiotics.
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How Is Lyme Disease Treated
With early-stage Lyme disease, youâll take antibiotics for about 10 days to 3 weeks. The most common ones are amoxicillin, cefuroxime, and doxycycline. The antibiotics will almost always cure your infection. If they donât, you might get other antibiotics either by mouth or as a shot.
If you donât treat your Lyme infection, you might need oral antibiotics for symptoms like weakened face muscles and irregular heartbeat. You may need antibiotics if you have meningitis, inflammation in your brain and spinal cord, or more severe heart problems.
If your Lyme is late stage, the doctor might give you antibiotics either by mouth or as a shot. If it causes arthritis, youâll get arthritis treatment.
Thereâs no therapy for post-treatment Lyme disease syndrome.
How Can Lyme Disease Last For Years
Category: Health Published: October 9, 2015
If treated, Lyme disease does not last for years. However, for some people, the after-effects of the disease can linger for months and sometimes even years. Alternative medicine providers call this condition “Chronic Lyme disease,” but this title is simply wrong. For a person who has been infected with Lyme disease and then treated, the bacteria that causes Lyme disease is measurably no longer present in his body, even though he may still feel some symptoms. The correct title for this condition is therefore “Post-treatment Lyme Disease Syndrome.”
Lyme disease is an infection caused by a bacteria known as Borrelia burgdorferi. This bacteria is delivered to humans through tick bites. From the bite site, the bacteria can enter the bloodstream and spread throughout the body. Usually, but not always, an infectious tick bite causes a characteristic red rash at the site of the bite. Other symptoms include fever, muscle soreness, headache, fatigue, and dizziness. In a few cases, symptoms can also include mood swings, memory loss, and sleep disturbance. If left untreated for too long, Lyme disease can lead to nerve damage, thereby causing shooting pain, numbness, and even paralysis.
The CDC states,
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What If A Tick Bites My Dog
The more ticks in your region, the likelier it is that your furry pal will bring them home.
Your dog is much more likely to be bitten by a tick than you are. And where Lyme disease is common, up to 25% of dogs have had it at some point.
About 10% of dogs with Lyme disease will get sick. 7-21 days after a tick bite, your dog might seem like theyâre walking on eggshells. They also might have a fever and enlarged lymph nodes. Plus, they might seem tired. Dogs also get antibiotics for Lyme.
What if my dog brings ticks into my home?
Use a tick control product on your pet to prevent Lyme disease. Also, have your dog vaccinated against Lyme.
Check your dogâs whole body each day for bumps. If you notice a swollen area, see if thereâs a tick there. If you find a tick, wear gloves while you use tweezers to separate it from your dog. Then, put it in soapy water or alcohol, or flush it down the toilet.
Use alcohol to clean the spot on your dog where the tick was attached. Keep an eye on that spot, and also on your dog to make sure theyâre behaving normally. If you notice any changes, check with your vet.
John Aucott, MD, assistant professor of medicine, Johns Hopkins University School of Medicine director, Johns Hopkins Lyme Disease Clinical Research Center.
Morbidity and Mortality Weekly Report: âVital Signs: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004-2016.â
American College of Rheumatology.
What Are The Symptoms Of Lyme Disease
Symptoms can start anywhere from 3 to 30 days after the bite. They may look different depending on the stage of your infection. In some cases, you wonât notice any symptoms until months after the bite.
Early symptoms include:
All of those symptoms are also common in the flu. In most Lyme infections, one of the first symptoms youâll notice is a rash.
Without treatment, symptoms can get worse. They might include:
- Severe headache or neck stiffness
- Rashes on other areas of your body
- Arthritis with joint pain and swelling, particularly in your knees
- âDroopingâ on one or both sides of your face
- Inflammation in your brain and spinal cord
- Shooting pains, numbness, or tingling in your hands or feet
What does the rash look like?
Some Lyme rashes look like a bull’s-eye with circles around the middle. But most are round, red, and at least 2 inches across.
The rash slowly gets bigger over several days. It can grow to about 12 inches across. It may feel warm to the touch, but itâs usually not itchy or painful. It can show up on any part of your body.
How small are ticks?
Ticks come in three sizes, depending on their life stage. They can be the size of a grain of sand, a poppy seed, or an apple seed.
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Can You Beat Lyme Disease Without Antibiotics
The use of antibiotics is critical for treating Lyme disease. Without antibiotic treatment, the Lyme disease causing bacteria can evade the host immune system, disseminate through the blood stream, and persist in the body.
Does Lyme disease affect your knees?
The main feature of Lyme arthritis is obvious swelling of one or a few joints. While the knees are affected most often, other large joints such as the shoulder, ankle, elbow, jaw, wrist, and hip can also be involved. The joint may feel warm to the touch or cause pain during movement.
Banderol And Cats Claw
These two herbs are commonly dosed together because they work synergistically with clinically proven action against Borrelia species, Greenspan says. The goals with any treatment with Lyme disease spirochetes, whether chronic or acute, is to have a combination of herbs to be effective with the shape-shifting behavior of this microbe.
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What Is The Treatment For Lyme Disease
The first-line standard of care treatment for adults with Lyme disease is doxycycline, a tetracycline antibiotic. Other antibiotics that have activity against borrelia include the penicillin-like antibiotic, amoxicillin, and the second generation cephalosporin, Ceftin. The mainstay of treatment is with oral antibiotics, but intravenous antibiotics are sometimes indicated for more difficult to treat cases of neurologic-Lyme disease, such as meningitis, and cases of late Lyme arthritis.
Protect Yourself From Tick Bites
Know where to expect ticks. Blacklegged ticks live in moist and humid environments, particularly in and near wooded or grassy areas. You may get a tick on you during outdoor activities around your home or when walking through leaves and bushes. To avoid ticks, walk in the center of trails and avoid walking through tall bushes or other vegetation.
Repel ticks on skin and clothing. Use Environmental Protection Agency -registered insect repellents containing DEET, picaridin, IR3535, oil of lemon eucalyptus, para-menthane-diol, or 2-undecanone. EPAs helpful search tool can help you find the product that best suits your needs. Always follow product instructions. Parents should apply this product to their children, avoiding hands, eyes, and mouth. Use products that contain permethrin on clothing. Treat clothing and gear, such as boots, pants, socks and tents with products containing 0.5% permethrin. It remains protective through several washings. Pre-treated clothing is available and may be protective longer.
- The Environmental Protection Agency has an online tool to help you select the repellentexternal icon that is best for you and your family.
- For detailed information about preventing ticks on pets and in your yard, see Lyme Disease Prevention and Control.
- For detailed information for outdoor workers, see NIOSH Safety and Health Topic: Tick-borne Diseases.
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Potential Treatment For Lyme Disease Kills Bacteria That May Cause Lingering Symptoms Study Finds
Screening thousands of drugs, Stanford scientists determined that in mice, azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease.
Deer ticks are vectors of Borrelia burgdorferi, the bacteria that causes Lyme disease.Scott Bauer/USDA Agricultural Research Service
For decades, the routine treatment for Lyme disease has been standard antibiotics, which usually kill off the infection. But for up to 20% of people with the tick-borne illness, the antibiotics dont work, and lingering symptoms of muscle pain, fatigue and cognitive impairment can continue for years sometimes indefinitely.
A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. The study suggests it could also be effective for treating patients infected with drug-tolerant bacteria that may cause lingering symptoms.
This compound is just amazing, said Jayakumar Rajadas, PhD, assistant professor of medicine and director of the Biomaterials and Advanced Drug Delivery Laboratory at the Stanford School of Medicine. It clears the infection without a lot of side effects. We are hoping to repurpose it as an oral treatment for Lyme disease. Rajadas is the senior author of the study, which was published online March 2 in Scientific Reports. The lead author is research associate Venkata Raveendra Pothineni, PhD.
Other Natural Treatments For Lyme Disease
The treatments discussed above are only some of the natural treatments that claim to treat Lyme disease. According to a 2015 study looking at the alternative treatments found during an Internet search, other natural treatments people use for Lyme disease include:
- saunas and steam rooms
The investigators noted that theres no research backing up these treatments, any many dont have a logical rationale behind them.
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Hyperbaric Oxygen Therapy For Lyme Disease
Hyperbaric oxygen therapy involves exposure to 100 percent oxygen at a high pressure. Its often in a room called a hyperbaric oxygen chamber to promote wound healing.
There isnt much research about the effectiveness of hyperbaric oxygen therapy for Lyme disease. But a 2014 case study from Taiwan reports that it treated Lyme disease in a person who hadnt responded to antibiotics. Still, more large-scale studies are needed to understand whether its an effective treatment.
What About Testing For Intestinal Parasites In Lyme Disease
Even though testing is not perfect, consider sending three separate stool samples to the lab, for an ova and parasite microscope test, to see if parasites can be identified. If possible, use a high-quality intestinal parasite lab like Genova Diagnostics. Also consider having an enzyme immunoassay test performed for common parasites. This type of test attaches a marker to parts of parasites, so they can be seen. EIA testing can find common parasites 90 percent or more of the time when they are present. Yet, such testing does not exist for all types of parasites.
The reason to test is to see if the type of parasite is known. If you know which parasite you have, then the treatment option is to use a prescription antiparasitic for that specific parasite.
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Tobacco To Turn Off Ticks
Birds get ticks, too. The house finch has developed a strategy to fight ticks. A study in the Avian Biology journal has shown that breeding house finches use cigarette stubs to proof their nests. The nicotine wards off parasites, but sadly the neurotoxin can also have negative effects on the chicks.
Ticks a plague for humans and animals alike
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