Tuesday, July 16, 2024

Lyme Disease Antibody W Reflex To Wb

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Question 8 Is There A Test To Prove Cure For Lyme Disease

Reliability of Lab Testing for Lyme Disease

There is no test to prove cure for Lyme disease. Antibodies frequently persist in the blood for months or even years after the infection is resolved, despite absence of detectable/viable B burgdorferi.7 Therefore, antibody tests cannot be used to determine a cure. There is no evidence that antibiotics cause Lyme serology blood tests to become negative following treatment.3,5,6

Lyme Disease Total Antibodies Blood Test

In the aiding of the diagnosis of acute or chronic infections with Lyme Disease, the Lyme Disease Antibodies, Total Immunoglobin IgG/Igm test is useful.

The test can both detect IgM and IgG antibodies but doesnt distinguish between the two.IgM antibodies develop in a short time after infection and vanish after a few months. IgG antibodies start to develop many weeks after infection and continue to exist.

Contact with the bacteria Borrelia burgdorferi cause the infection that lead to Lyme Disease.

Untreated Lyme Disease causes joint pain, arms and hands numbness, facial paralysis, Meningitis, heart problems or memory problems.

Testing for Lyme Disease is advised when a person experiences symptoms associated with the Lyme Disease, especially if they recently had a tick bite or have been in an area where Lyme Disease is prevalent.

The test is recommended when someone have been infected with Lyme Disease but doesnt know the onset of the infection.

Results are typically returned within 1 business days. We take every precaution to ensure you receive your results on time.

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Lyme Disease Is Remarkably Difficult To Diagnose

The problem with Lyme disease is that the bacteria can create a hard âshellâ around themselves when inactive so that the blood tests are unable to detect them. This is especially true when the disease has reached the chronic stage. The timing of the symptoms is often used by a medical provider to establish a time line to a tick bite or exposure to a high-risk region where the disease is commonly transmitted.

Because the ticks that can spread Lyme disease are often the size of a pinhead, the ticks might not even be notice. A bulls-eye rash at the bite location is a trademark symptom of Lyme disease, but only about half of the people who are infected with the bacteria develop the rash. Once the disease reaches the chronic stage, chronic arthritis, joint pain, and neurological symptoms begin to appear, sometimes several months after the infection.

Also Check: How Do You Test For Chronic Lyme Disease

When Is The Lyme Disease Blood Test Ordered

When someone has the signs and symptoms of Lyme disease or they live in a region that has deer ticks or black-legged ticks, then this blood test will be ordered. It will also be ordered when these symptoms occur without improvement over the course of 7-14 days by most medical providers.

  • A bulls-eye rash that grows from the bite site.
  • Fevers, chills, and a persistent headache that does not go away.
  • Unusual and persistent fatigue that does not immediately improve.

The IgM and IgG tests are generally ordered first when Lyme disease is suspected. This is because people who have never been exposed to the bacteria that causes the disease will not have any antibodies present. If these tests are positive and followed up by a positive Western Blot test, then the chances are very good that Lyme disease is present. This is especially true if antibody levels continue to rise over time.

Lyme Disease Western Blot Test

The Lyme Disease Western Blot test is typically used as a confirmatory test for people who have had positive results from previous Lyme Disease testing. The immunoblot test is also known as a Lyme Disease Line Blot test. This test looks for the presence of both IgG and IgM antigen bands to confirm both recent and previous exposure. The detection of multiple bands is required for a positive result. The CDC does not recommend the Western Blot test as a front-line screening as some conditions other than Lyme Disease may cause a false positive.

Lyme Disease is caused by infection with the bacteria Borrelia burgdorferi. It is most commonly spread by the Deer Tick or Black Legged Tick and is the most common tick-borne illness in the United States and Europe. Lyme disease can be difficult to diagnose because the symptoms are often similar to other afflictions. While some people will display a distinctive “bulls-eye” rash around the site of the bite, others may experience common flu-like symptoms such as fever, chills, fatigue, and headache. The ticks which spread the disease are typically very small and many people do not even realize they have been bitten. If left untreated, Lyme Disease can cause joint pain, numbness in the arms and legs, facial paralysis, Meningitis, heart problems, or memory problems.

Turnaround time for the Lyme Disease Immunoblot test is typically 1-5 business days.

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Question 10 What Other Infections Can A Tick Transmit To Humans Besides Lyme Disease

I scapularis ticks can also carry other human pathogens that have a high degree of symptom overlap, including Borrelia miyamotoi, Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Babesia microti.2,10-12 Several studies on co-infected ticks indicate as many as 20% of Ixodid ticks can be coinfected with B burgdorferi and one or more of these other tick-borne human pathogens.10-12

Molecular tests can be useful to detect these organisms in early/acute stages of infection, when genetic material from the pathogen can be detected but antibodies remain below the limit of detection of serologic assays.2,10-12 Quest offers molecular and/or serological tests for B burgdorferi, B miyamotoi, A phagocytophilum, E chaffeensis, and B microti, individually and in 2 panels .

  • Fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes
  • Erythema migrans rash:
  • Occurs in approximately 70 to 80 percent of infected persons
  • Begins at the site of a tick bite after a delay of 3 to 30 days
  • Expands gradually over a period of days reaching up to 12 inches or more across
  • May feel warm to the touch but is rarely itchy or painful
  • Sometimes clears as it enlarges, resulting in a target or bulls-eye appearance
  • May appear on any area of the body

Question 5 How Do The Sttt And Mttt Detection Methodologies Compare

The MTTT appears to provide similar or improved sensitivity and specificity compared to the STTT. In a 356-sample retrospective study of a heterogenous cohort, specimens from healthy and disease control subjects and patients characterized as having stage I , stage II , or stage III Lyme disease were tested with both the STTT and MTTT approach.4 The results are summarized in Table 1. The MTTT methodology showed improved sensitivity relative to STTT for Lyme stages I and II, with statistically comparable sensitivity for stage III Lyme disease specificity did not differ significantly between the 2 methods.4

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Her ordeal is a common one every year, some 300,000 people in the United States are diagnosed with Lyme disease, according to the Centers for Disease Control and Prevention, and that number is on the rise. Some people wait months or years to get a correct Lyme diagnosis. And their cases highlight a problem: Tests for Lyme in the first month of infection are frequently wrong. When diagnosed and treated early the infection is a simple one to get rid of, but left untreated it can cause a myriad of lingering symptoms, from severe arthritis to short-term memory problems.

Now, a number of research groups are working to improve Lyme tests to catch infections in the early stages. One avenue being studied by the CDC aims to create a Lyme signature of small molecules in the blood an approach that, in early testing, catches a dramatically higher share of early infections.

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What Happens During Lyme Disease Testing

Emerging tick-borne diseases in Australia – Video abstract: 27336

Lyme disease testing is usually done on a sample of blood. In certain cases, a cerebrospinal fluid test may be done.

For a Lyme disease blood test:A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

For a CSF test:You may need a cerebrospinal fluid test if your symptoms could mean that Lyme disease is affecting your nervous system, such as a stiff neck or numb hands or feet. Providers may order a CSF test if the results of your blood test show you likely have Lyme disease or if the results are uncertain.

To get a sample of your cerebrospinal fluid, a provider will do a procedure called a lumbar puncture, also known as a spinal tap. During the procedure:

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Lyme Disease Ab With Reflex To Blot

The Lyme Disease Ab with Reflex to Blot test contains 1 test with 1 biomarker.

Description: The Lyme disease antibody test is testing for Borrelia antibodies. Borrelia is the bacteria that causes Lyme Disease. The immune system produces antibodies to fight against the infection of Borrelia, or Lyme disease.

Also Known As: Borrelia burgdorferi Test, Lyme Disease Antibodies IgG IgM Immunoblot Test, Lyme Disease antibodies Test

Collection Method: Blood Draw

Test Preparation: No preparation required

When is a Lyme Disease Antibody test ordered?

When a person shows signs and symptoms of Borrelia infection and lives in or has visited a place where deer ticks, also known as black-legged ticks, are abundant, especially if the person has recently been bitten by a tick, Lyme disease testing is required.

Testing may be repeated after a few weeks if initial testing is negative but the suspicion of Lyme disease remains strong.

When a person does not have typical Lyme disease symptoms or a history of tick bites, and has not traveled to a Lyme disease-endemic area, a healthcare provider may rule out alternative possibilities before diagnosing and testing for Lyme disease.

What does a Lyme Disease Antibody blood test check for?

The bacteria Borrelia burgdorferi and Borrelia mayonii, which are transported predominantly by the deer tick, often known as the black-legged tick, cause Lyme disease. Borrelia antibodies in the blood are measured in Lyme disease tests.

  • Babesia Microti Antibodies

Later Signs And Symptoms

  • Severe headaches and neck stiffness
  • Additional EM rashes on other areas of the body
  • Arthritis with severe joint pain and swelling, particularly the knees and other large joints.
  • Facial or Bell’s palsy
  • Intermittent pain in tendons, muscles, joints, and bones
  • Heart palpitations or an irregular heart beat )
  • Episodes of dizziness or shortness of breath
  • Inflammation of the brain and spinal cord
  • Shooting pains, numbness, or tingling in the hands or feet
  • Problems with short-term memory

Also Check: What Are The Symptoms Of Neurological Lyme Disease

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Are There Any Risks To Lyme Disease Tests

There is very little risk to having a blood test or a lumbar puncture.

With a blood test, you may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.

With a CSF test, you may feel a little pinch or pressure when the needle is inserted. After the test, you may feel some pain or tenderness in your back where the needle was inserted.

You may also have some bleeding at the site or get a headache. The headache may last for several hours or up to a week or more, but your provider may suggest treatment to help relieve the pain.

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Early Signs And Symptoms

  • Fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes
  • Erythema migrans rash:
  • Occurs in approximately 70 to 80 percent of infected persons
  • Begins at the site of a tick bite after a delay of 3 to 30 days
  • Expands gradually over a period of days reaching up to 12 inches or more across
  • May feel warm to the touch but is rarely itchy or painful
  • Sometimes clears as it enlarges, resulting in a target or bull’s-eye appearance
  • May appear on any area of the body

Lyme Disease Ab Total W Reflex To Wb

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What Do The Results Mean

Lyme disease is difficult to diagnose. The symptoms are common to many conditions, and test results alone can’t diagnose the disease. To make a diagnosis, your provider will consider your test results along with your medical history, exposure, and symptoms. You may also need other tests.

A negative blood test result means that antibodies to fight the Lyme disease bacteria were not found in your blood. If you had symptoms for longer than 30 days before your test, you probably don’t have Lyme disease.

But if you had symptoms for less than 30 days before you gave your blood sample, you may need to have another Lyme disease test. That’s because it may take a few weeks for your body to make enough antibodies to show up on a test. If your test was done too soon, you could be infected even though your test was negative. This is called a “false negative.”

A positive blood test result means that antibodies to fight the Lyme disease bacteria were found in your blood. In this case, the Centers for Disease Control and Prevention recommends a second blood test on the same blood sample. If the second test is positive and you have symptoms of infection, you probably have Lyme disease.

But positive test results don’t always mean that Lyme disease is causing your symptoms. You could have antibodies from a past case of Lyme disease that your body successfully fought off months or even years ago.

Learn more about laboratory tests, reference ranges, and understanding results.

What Does It Mean If Your Lyme Disease Ab Blot Result Is Too High

My chronic Lyme disease symptoms part 3…List of complete symptoms below

Two types of antibodies are detected in the Western blot test.

IgM antibodies reflect a relatively recent infection. IgG antibodies in contrast are a sign of an older infection.

IgM antibodies usually disappear after eight weeks post-exposure. IgG remains in the serum for a very long time.

In the Western blot test there are three bands for IgM and 10 bands for IgG.

Here is the important part:

You need to have 2 out of 3 for the positive IgM result

Or you need to have 5 out of 10 for the positive IgG result.

This marker is called Lyme Disease AB , Blot and is an aggregate marker for the three IgM results. So if this marker is positive you have at least 2 out of 3 of the IgM markers positive.

Here is the 2nd important part when it comes to a diagnosis:

If a person doesnt have signs or symptoms of Lyme disease, then the person does not have Lyme disease as the definition of disease requires symptoms.

What could some of those symptoms be?

What are the symptoms of Lyme disease?

Lyme disease symptoms are wide-ranging, with more than a hundred different symptoms recorded. Symptoms can also change over time, as the bacteria spreads throughout the body. To make things more confusing, Lyme disease symptoms will also vary from patient-to-patient. Lyme disease can mimic hundreds of other conditions since its symptoms mirror many medical problems such as multiple sclerosis, arthritis, chronic fatigue syndrome or lupus, and is sometimes known as The Great Imitator because of this.

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Lyme Disease Antibody With Reflex To Blot


CPT Code: 86618Order Code: C1473Includes: Lyme Disease Ab ScreenIf Lyme Disease Ab Screen is 0.90, then Lyme Disease Ab , Blot and Lyme Disease Ab , Blot will be performed at an additional charge .ABN Requirement: NoContainer: Gel-barrier tube


  • Collect and label sample according to standard protocols.
  • Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  • Let tube stand in a vertical position to allow blood to clot 30 minutes.
  • Centrifuge for 10 minutes.
  • Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions included with the provided shipping box.


    Ambient : 7 daysRefrigerated : 14 daysFrozen : 30 days

    Causes for Rejection: Specimens other than serum improper labeling samples not stored properly samples older than stability limits grossly hemolyzed, grossly lipemic, or grossly icteric samples

    Methodology: Immunoassay Reflex: Immunoblot

    Turn Around Time: 3 to 4 days

    Reference Range:

    > 1.09

    Clinical Significance: Lyme Disease Antibody with Reflex to Blot Lyme disease is caused by a bacterium borrelia burgdorferi and is transmitted by ticks. A screening test with high sensitivity is used as the first step in the CDC recommended algorithm. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patients specimen. Immunoblot testing is appropriate for confirming a detected screening result.


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