Azlocillin Comes Out On Top
The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.
Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.
Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.
Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD senior research scientist Mohammed Inayathullah, PhD and intern Mohamed Sohail Ahmed.
A researcher at Loyola College in India also contributed to the work.
The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.
- Tracie White
Lyme The Nervous System And Neuropathy
Unfortunately, once the infection begins to spread throughout the body, many people will develop Lyme neuroborreliosis . This is neurological Lyme disease, which affects and inflames the central and peripheral nervous systems.
Research suggests the neurologic manifestations of Lyme disease may be present in approximately 15% of the patient population. However, the exact incidence of LNB isnt well known. A brief stint in an online Lyme patient forum will quickly reveal that most individuals report experiencing at least some amount of neurological involvement on a routine basis.
One debilitating symptom that may be present among those with LNB is peripheral neuropathy . This is a disease process that impacts the nerves located outside of the brain and spinal cord. Neuropathy occurs when there is damage or dysfunction of neurons in one or more nerves.
The damage results in interference among the neurons, and they begin to have difficulty communicating with each other and the brain.
To make matters worse, co-infections like Babesia and Bartonella can contribute to neuropathy as well, according to a study in the International Journal of General Medicine.
So how do you know if the symptoms youre facing are neuropathy, and what can you do to find some relief? Read on to learn about the symptoms, diagnosis, and ideas on how to manage the pain and discomfort associated with neuropathy more effectively.
For Depression And Anxiety
Both psychotherapy and pharmacotherapy have proven benefits for improving mood. Psychotherapy has many different types such as supportive, dynamic, cognitive behavioral, dialectical behavior therapy, transference focused psychotherapy each of which offers benefit. Pharmacotherapy also has many different types. For depression the first-line options usually are SSRIs, SNRIs, Tricyclics or other agents with more unique modes of action.
A few noteworthy tips on anti-depressant agents:
- Most anti-depressant agents also help in reducing anxiety. However the opposite isn’t necessarily true. Specific anti-anxiety agents such as clonazepam or diazepam may not necessarily help fight depression.
- Most anti-depressants take three to eight weeks before an effect is seen. Therefore, it is unwise to stop an anti-depressant after only three or four weeks, as staying on it another two to three weeks may lead to a good response.
- Dosage makes a difference. Some anti-depressants work fine at low doses some medications however are effective only at higher doses. Some medications are more effective as the dose is increased. Other antidepressants may have a therapeutic range one has to achieve at least a certain dosage .
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An Alternative Method Of Attaining Relief
People with Lyme disease who are unable to take antibiotics, or who developed PTLDS because antibiotics were not effective, are often desperate to find a treatment that works. According to the CDC, patients with PTLDS usually get better over time, but many months can pass before they feel completely well. Ideally, they would find a treatment that supports the bodys detoxification processes, stimulates normal cell activity, and reduces inflammation.
Actually, there are two methods available today that help achieve these functions: heat and light.
The Healing Properties Of Heat
Heat, like the kind of intense heat youd experience in a sauna, is a therapy thats been around for millennia. Saunas produce enough heat to make the body a less welcoming host for bacteria by raising the bodys core temperature and encouraging profuse sweating, which releases toxins through the skin. This reduces the burden on the liver and kidneys.
Saunas increase blood flow to aid with the detoxification process and to bring needed nutrients to all parts of the body. Saunas also activate heat shock proteins. These proteins are produced by cells in response to stressful conditions but they are now known to be present during wound healing or tissue regeneration. Activating these proteins artificially, via heat, can help stimulate the healing process.
The Benefits Of Red Light Therapy
Lyme And Neuropathy: How To Ease Nerve Pain Tingling And Weakness
Lyme disease can affect several systems of the body the brain, nervous system, joints, heart, and more.
The list of symptoms infected individuals can experience is expansive and varies from person to person.
Its one of the reasons a Lyme disease diagnosis may be controversial.
Yet, one thing everyone seems to agree on about the tick-borne disease is that it can significantly impact the nervous system, especially without prompt treatment in the early stages of the infection.
Unfortunately, Lyme often goes missed early on. The telltale sign of a Lyme infection an erythema migrans rash, or the classic bulls-eye rash doesnt occur in every case. .
And the initial symptoms of infection may be nothing more than fever, chills, headache, fatigue, or muscle aches, making them easy to miss or brush off as a case of the flu.
But as the disease advances, the bacteria associated with Lyme, Borrelia burgdorferi, spreads via the bloodstream to other parts of the body, a process known as dissemination. This occurs in the days and weeks following infection, referred to as early disseminated Lyme disease.
If an infection goes untreated for months to years, however, theres a good chance the infection will proceed to late stage or late disseminated Lyme disease, sometimes called chronic Lyme disease. Thats when the nervous system can become involved, and symptoms ratchet up to a whole new level.
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Strategies For Managing Nerve Pain
1. Reduce Your Microbial Burden
When youre dealing with Lyme disease and co-infections, its not always easy to pinpoint which stealth pathogen is affecting your nervous system. In fact, its most reasonable to recognize that all sneaky microbes are capable of disrupting immune function and causing it to go awry.
When your bodys microbial burden becomes too great, your microbiome becomes imbalanced, driving inflammation and aggravating neuropathy. Thus, at the top of the priority list is decreasing the infectious load to normalize and calm the immune system.
When youre looking for natural solutions to lessen the impact of stealth pathogens, herbal therapy can play a critical role. Not only do herbs have antimicrobial properties, but they are anti-inflammatory and contain antioxidants as well.
Moreover, herbs dont disrupt the delicate balance of the microbiome like synthetics medications do. Some of my favorite herbs with antimicrobial and immunomodulating properties to keep in mind include:
2. Use Medications Cautiously
When it comes to neuropathy, the reality is that sometimes you need some extra support to get your pain levels to a tolerable level. There are a variety of over-the-counter and prescription medications that may be useful from time to time.
However, the value of medications is limited to short term management of symptoms because of cumulative side effects. The list of medications commonly recommended by healthcare providers includes:
Natural Cure For Lyme Disease What Happens When A Tick Bites You Out Of The Blue
Would you believe that a single bite of a tiny organism like a tick can make you suffer from some serious symptoms that can last for a whole lifetime? Relax! Because here is everything that you need to know about the Lyme disease and the best natural cure for Lyme disease which will ease your symptoms and make you free of this illness.
What Is Lyme Disease And What Causes Lyme Disease?
Lyme disease is caused by a tiny insect which is commonly known as a deer tick or a black-legged tick. When an infected black-legged tick bites you, it releases a bacterium which is the original underlying cause of Lyme disease. To make it much clear, Lyme disease is not usually caused by a deer tick but you could acquire this disease if you are stung by an infected deer tick that carries a bacteria called Borrelia burgdorferi. So, the bacteria are what causes Lyme disease.
An interesting fact that you should be aware of is that the so-called deer tick or the black-legged tick is so tiny you can hardly notice it. The size of a tick can be compared to that of a mustard seed. You may not be able to sense the bite of this tick as it releases its saliva onto your skin before it stings you which can make your skin numb and senseless.
You can only recognize that you are infected with Lyme disease when you begin to experience the Lyme disease symptoms which have been mentioned below, the impact of which can be definitely reduced through a natural cure for Lyme disease.
Is Lyme Disease Curable?
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Natural Remedies For Lyme Disease
Lyme disease is a bacterial infection caused by the bacterium Borrelia burgdorferi. It is spread through the bite of infected ticks.
Ticks are very small, and their biteswhich can occur anywhere on the bodyare usually painless, so you may not immediately be aware that you have been bitten. In most cases, the tick must be attached to the body for 24 hours before Lyme disease is transmitted.
The signs and symptoms of Lyme disease usually start within three to 30 days after youve been bitten by an infected tick. Many people experience flu-like symptoms after being bitten, while more serious symptoms show up weeks after the bite. Early signs and symptoms of Lyme disease include:
- Swollen lymph nodes
If left untreated, symptoms can worsen to include Bells palsy , severe headaches, muscle, joint, and tendon pain, cardiac problems, and neurological disorders.
Most cases of Lyme disease can be managed and treated with two to three weeks of antibiotics. Depending on the severity of your symptoms and how long after the bite you were diagnosed, you may need a longer course of antibiotics to clear up the infection. Many people turn to natural remedies to help treat Lyme disease.
What Do I Do If I Find A Tick On My Skin
Dont panic. Use fine-tipped tweezers to grasp the tick as close to the skins surface as possible. Pull up with steady, even pressure. Be careful not to squeeze or twist the tick body. Sometimes parts of the tick remain in the skin. You can leave them alone or carefully remove them the same way you would a splinter. Do not use heat , petroleum jelly, or other methods to try to make the tick back out on its own. These methods are not effective.
Wash the area where the tick was attached thoroughly with soap and water. Keep an eye on the area for a few weeks and note any changes. Call your doctor if you develop a rash around the area where the tick was attached. Be sure to tell your doctor that you were bitten by a tick and when it happened.
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What Is Lyme Disease
Lyme disease is a bacterial infection. You get it when the blacklegged tick, also known as a deer tick, bites you and stays attached for 36 to 48 hours. If you remove the tick within 48 hours, you probably wonât get infected.
When you do get infected, the bacteria travel through your bloodstream and affect various tissues in your body. If you donât treat Lyme disease early on, it can turn into an inflammatory condition that affects multiple systems, starting with your skin, joints, and nervous system and moving to organs later on.
The chances you might get Lyme disease from a tick bite depend on the kind of tick, where you were when it bit you, and how long the tick was attached to you. Youâre most likely to get Lyme disease if you live in the Northeastern United States. The upper Midwest is also a hot spot. But the disease now affects people in all 50 states and the District of Columbia.
Treatment Of Lyme Disease
Early diagnosis and proper antibiotic treatment of Lyme disease is important and can help prevent late Lyme disease. The following treatment regimens reflect CDCs interpretation of the most current data for four important manifestations of Lyme disease. These regimens are consistent with guidanceexternal icon published by the by the Infectious Disease Society of America, American Academy of Neurology, and American College of Rheumatology.
Some patients report persistent symptoms of pain, fatigue, or difficulty thinking even after treatment for Lyme disease. The state of the science relating to persistent symptoms associated with Lyme disease is limited, emerging, and unsettled.
Additional researchexternal icon is needed to better understand how to treat, manage, and support people with persistent symptoms associated with Lyme disease. In light of these research gaps, recommendations for treatment of persistent symptoms in people previously treated for Lyme disease are not provided here.
If you are interested in information on chronic Lyme diseaseexternal icon, see NIHs website.
Links with this icon indicate that you are leaving the CDC website.
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Early Lyme Disease Treatment
ILADS doctors are likely to recommend more aggressive and longer antibiotic treatment for patients. They may, for instance, treat high risk tick bites where the tick came from an endemic area, was attached a long time, and was removed improperly. They may treat a Lyme rash for a longer period of time than the IDSA recommends, to ensure that the disease does not progress. They are unlikely to withhold treatment pending laboratory test results.
What Is Post Treatment Lyme Disease
Post Treatment Lyme Disease represents a research subset of patients who remain significantly ill 6 months or more following standard antibiotic therapy for Lyme disease. PTLD is characterized by a constellation of symptoms that includes severe fatigue, musculoskeletal pain, sleep disturbance, depression, and cognitive problems such as difficulty with short-term memory, speed of thinking, or multi-tasking. In the absence of a direct diagnostic biomarker blood test, PTLD has been difficult to define by physicians, and its existence has been controversial. However, our clinical research shows that meticulous patient evaluation when used alongside appropriate diagnostic testing can reliably identify patients with a history of previously treated Lyme disease who display the typical symptom patterns of PTLD.
Who Gets Lyme Disease
Anyone bitten by an infected deer tick can get Lyme disease. Most U.S. cases of Lyme disease happen in Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia, and Wisconsin. But Lyme disease is also found in other parts of the U.S., Europe, and Asia.
Other things that might increase a person’s risk include:
- spending a lot of time outdoors in tall grass, brush, shrubs, or wooded areas
- having pets that may carry ticks indoors
- activities such as yardwork, hiking, camping, fishing, or hunting in tick-infested areas
How Can I Take Cannabis For Lyme Disease
In order for cannabis to be effective at fully eliminating the bacteria that causes Lyme disease from your body as well as reverse the long-term damage to your nervous and immune system, we suggest eating as much cannabis oil or cannabis in edible form as possible. Merely smoking it will not cure your Lyme disease, but may aid in pain and nausea relief as well as help you sleep.
Eating cannabis tincture, cannabis pills, cannabis drinks, or cannabis edibles may help control your symptoms. If you take cannabis oil or pills, you may want to take as much as you can afford as these products are expensive. Sprinkle flax seeds on your food at every meal you can, as they naturally contain CBD.
Vaporizing cannabis is better than smoking cannabis in a joint, pipe, or bong because it doesnt burn the cannabis. Smoking cannabis releases toxins similar to cigarettes, can cause lung irritation and often disintegrates cannabinoids with healing properties. Vaporizing cannabis heats the air around the cannabis, releasing a range of cannabinoids, each with unique health benefits.
A new way to get cannabis into your body is via a transdermal patch, similar to the birth control patch or the nicotine patch. This discrete method provides extended release medication for up to ten hours and is perfect for people who feel uncomfortable with other methods such as smoking cannabis.
Cannabis topicals, in the form of creams or lotions you put on your skin, can help with pain and spasms during the day.
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Who’s At Risk And Where Are Ticks Found
The risk of getting Lyme disease is higher:
- for people who spend time in woodland or moorland areas
- from March to October because more people take part in outdoor activities
Ticks are found throughout the UK and in other parts of Europe and North America. There are a high number of ticks in the Scottish Highlands.
It’s thought only a small proportion of ticks carry the bacteria that cause Lyme disease. Being bitten doesn’t mean you’ll definitely be infected. However, it’s important to be aware of the risk and speak to a GP if you start to feel unwell.