Azlocillin Comes Out On Top
The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.
Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.
Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.
Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD senior research scientist Mohammed Inayathullah, PhD and intern Mohamed Sohail Ahmed.
A researcher at Loyola College in India also contributed to the work.
The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.
- Tracie White
What Does Current Guidance Say On This Issue
NICE guidance on Lyme disease states that those without focal symptoms should receive 100mg oral doxycycline twice a day or 200mg once per day for 21 days. The first alternative to this is oral amoxicillin, 1g three times per day for 21 days and the second alternative is oral azithromycin, 500mg daily for 17 days.
Is Amoxicillinas Effective As Doxycycline For Lyme Disease
You might be askingyourself, Can amoxicillin treat Lyme disease? The answer is yes. Anamoxicillin treatment for early Lyme disease is widely prescribed, but foramoxicillin to have the same efficacy as doxycycline, patients will have totake almost 10 times the amount 500 mg three times a day, for two to threeweeks. Deciding which antibiotic to go with depends on the patients ability tokeep up with the antibiotics course and how far along the disease hasprogressed.
Amoxicillin is alsoprescribed in patients who are pregnant because its still effective againstthe bacteria but doesnt pose the same risks as doxycycline on the pregnancyand unborn child. Doxycycline is also avoided in children under eight yearsold, whereas amoxicillin can be taken by children who have been infected withLyme.
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Prevention Of Tick Bites
The best currently available method for preventing infection with B. burgdorferi and other Ixodes-transmitted infections is to avoid tick-infested areas . If exposure to I. scapularis or I. pacificus ticks is unavoidable, a number of measures may help to decrease the risk that ticks will attach and subsequently transmit infection. The use of protective clothing may interfere with attachment by ticks by increasing the time required for ticks to find exposed skin, thus facilitating their recognition and removal. By wearing light-colored clothing , persons in areas of endemicity may also be more likely to see ticks before they have attached.
Daily inspections of the entire body to locate ticks also provide an opportunity to prevent transmission of tick-borne infections . Attached ticks should be removed promptly with fine-toothed forceps, if possible . Tick and insect repellents applied to the skin and clothing provide additional protection .
Tetracycline Plus Rifamycin Plus Disulfiram
- minocycline 100 mg 1 pill 2 times a day
- rifampin 300 mg 2 pills 1 time a day
- disulfiram 4 to 5 mg/ kg body weight. Work up to this dose slowly over 2 months then remain on the disulfiram at the peak dose for 4 months before tapering off.
- This minocycine and rifampin in this combination are as useful for treating a Bartonella co-infection. Co-infections are other germs passed on during a tick bite. If someone has a co-infection, when possible I choose antibiotic combinations that simultaneously treat Lyme germs and the co-infection germs.
- The disulfiram is added here to treat persister Lyme. Note disulfiram does not appear to treat Bartonella.
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Postlyme Disease Symptoms And Syndrome
The outcome of treatment in most patients with erythema migrans is excellent. Studies show, however, that when questioned at 6 months or more aftertreatment of erythema migrans, approximately 10% of patients will report purely subjective symptoms such as fatigue or musculoskeletal pains.17 These subjective symptoms are typically mild and may wax and wane in intensity. Patients who have them are referred to as having postLyme disease symptoms or syndrome, depending on the symptom duration and severity. The cause of these symptoms is currently unknown. Carefully done microbiologic evaluations in the United States have failed to find evidence of either persistentB. burgdorferi infection or a coinfection with a secondIxodes-transmitted pathogen. In patients with persistent symptoms attributed to Lyme disease, longer-term antibiotic treatment has been shown to have no additional beneficial effects on health-related quality of life beyond those with shorter-term treatment.A4 Furthermore, retreatment has provided either no measurable benefit or a benefit so modest or ambiguous that it was outweighed by the risks associated with the antibiotic therapy.17b Therefore, symptomatic treatment is recommended for such patients.
What Did It Find
- Compared to doxycycline, there was no difference between the following antibiotics for treatment response by 12 months: penicillin V , azithromycin , cefuroxime axetil , amoxicillin or ceftriaxone plus doxycycline .
- More than 80% of patients showed a treatment response, 84% at two or fewer months after starting treatment and 80% at 12 or more months following treatment initiation. There was no available data on outcomes for around 15%.
- There were few treatment failures in those people who were followed up 4% by two months and 2% by 12 months.
- Treatment-related adverse effects occurred in around 31% of people and included vomiting and diarrhoea as well as a Herxheimer-like reaction . Only 1% experienced haematologic adverse events, such as low platelet counts.
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Should I Call My Doctor Right Away Or Wait To See If I Develop Symptoms
ILADS recommends immediately contacting your health care provider. There are steps you can take to prevent a Lyme infection, as explained below. The onset of Lyme disease symptoms can be overlooked or mistaken for other illnesses. Once symptoms are more evident, the disease may have already entered the central nervous system, and could be hard to cure. Immediate care may prevent this from happening.
Possible Alternative Treatment For Lyme Disease
- University of Oklahoma
- Researchers have described a new antibiotic that appears to have the potential to cure Lyme disease.
As if COVID and RSV weren’t bad enough, incidents of Lyme disease — a potentially serious disease caused by the bacteria Borrelia burgdorferi and transmitted following a bite of an infected deer tick — also are on the rise in the United States.
Lyme disease affects an estimated 300,000 people in the United States alone. Humans and animals can be infected with B. burgdorferi following the bite of an infected deer tick, also known as the black-legged tick. About 80% of those who contract the disease will develop a bulls-eye rash around or near the site of the bite anywhere from three to 30 days following the bite.
Although early antibiotic treatment is effective for most patients, some 10-20% of patients continue to suffer from symptoms that may include fatigue, muscle pain and cognitive impairment for over six months after therapy. The significance of this debilitating disease has been recently brought into focus by a set of very similar symptoms in patients with “Long COVID.”
The antibiotics currently used to treat Lyme disease are broad-spectrum with significant effects on the human gut microbiome and the potential for increasing resistance in non-target bacteria, Zgurskaya explained, adding that the team sought to identify a compound acting with a narrower spectrum of activity against B. burgdorferi.
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What To Try If You Have Failed Years Of Antibiotics
In my practice for those that have failed years of regular antibiotics I offer two persister oriented regimes. Both of these regimens have some published clinical evidence of benefit. One regimen I offer is a Horowitz dapsone persister regimen. The other option I offer is a disulfiram only regimen or a disulfiram combination regimen . You can read more details about how to take both of these regimens in
Critical Appraisal Of Individual Studies
The included systematic review was critically appraised by one reviewer using AMSTAR II, the non-randomized study was assessed using the ROBINS-I Tool, and guidelines, were assessed with the AGREE II instrument. Summary scores were not calculated for the included studies rather, a review of the strengths and limitations of each included study were described narratively.
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Treatment For Chronic Lyme Disease
Sometimes, people go through treatment for Lyme disease but their symptoms donât go away. If this lasts over 6 months, itâs known as chronic Lyme disease or âpost-treatment Lyme disease syndromeâ .
Doctors still arenât sure why some people get PTLDS. Some believe that getting Lyme disease may cause damage to your tissues or immune system. Others believe itâs because the bacteria that causes Lyme hasnât completely gone away.
There is little evidence that taking more antibiotics at this stage will help. They may actually be harmful. Instead, your doctor will focus on treating the symptoms youâre still having. This will be different for everyone. Some people could benefit from a medicine that relieves fatigue, while others may need a drug that can help with headaches or very sensitive skin.
More research is needed to figure out how best to treat PTLDS. Itâs something that can be frustrating. Just remember: Many people who have this condition do start feeling like their old selves after a few months.
Are There Alternative Treatments For Lyme Disease
There are a variety of alternative treatments aimed at patients who believe they may have Lyme disease. But the effectiveness of these treatments is not supported by scientific evidence, and in many cases they are potentially harmful.
Bismacine, also known as chromacine, is an alternative-medicine drug that some people use to treat their Lyme disease.
The Food and Drug Administration warns that people should not use this injectable product, which has reportedly caused hospitalization and at least one death. 70563-1.pdf” rel=”nofollow”> 6)
In addition, the FDA notes that bismacine contains high levels of bismuth, which can cause heart and kidney failure.
Other alternative treatments include oxygen therapy, light therapy, and a variety of nutritional or herbal supplements. But there is no evidence that these treatments are clinically effective in the treatment of Lyme disease.
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Treatment For Other Forms Of Lyme Disease
People with other forms of disseminated Lyme disease may require longer courses of antibiotics or intravenous treatment with antibiotics such as ceftriaxone. For more information about treating other forms of Lyme disease, see:
The National Institutes of Health has funded several studies on the treatment of Lyme disease that show most people recover within a few weeks of completing a course of oral antibiotics when treated soon after symptom onset. In a small percentage of cases, symptoms such as fatigue and myalgia can last for more than 6 months. This condition is known as post-treatment Lyme disease syndrome , although it is also sometimes called chronic Lyme disease. For details on research into chronic Lyme disease and long-term treatment trials sponsored by NIH, visit the visit the National Institutes of Health Lyme Disease web siteexternal icon.
Lyme Disease Antibiotic Combination Examples
In my experience, I find the prescription antibiotic combinations below work 85 to 90 percent of the time. The herbal combination options help 85 to 90 percent of the time. I find all these combinations more successful than the Andrographis/Japanese knotweed/cats claw combinations that some like herbalist Stephen Harrod Buhner and Bill Rawls, MD, recommend. The Buhner/Rawls combination helps about 60 to 65 percent of the time in my clinical observations. To reach the success rates I describe here, it is essential to follow the first ten steps of The Ross Lyme Support Protocol to support the immune system.
Key Points: Each combination
- Combines antibiotics to treat all forms of the germ.
- Combines antibiotics to treat Lyme living outside and inside of cells.
- Combines antibiotics that work in different ways to attack the germ from different angles.
- Treats all growth phases of Lyme at the same time – this means treatments include antimicrobials that address persisters in addition to the growth phase of the term.
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Antimicrobial Herbs That Kill Growing Phase Spirochetes & Cysts
Intracellular and Extracellular
Based on my observations, these herbal combination options have as good of a chance as the prescription options. They appear to kill intracellular and extracellular Lyme too based on the clinical benefit I see in my medical practice.
- Cats Claw and Otoba Bark Tinctures 30 drops of each 2 times a day. Start at 5 drops 2 times a day and add 1 drop per dose per day until you reach 30 drops 2 times a day. If you get a Herxheimer reaction, stop increasing the dose until it has passed.
- Cats Claw and Japanese Knotweed 30 drops of Cats Claw 2 times a day and ½ tsp of Japanese Knotweed 3 times a day. Work up to these doses over 30 days. Start Cats Claw at 5 drops 2 times a day and add 1 drop per dose per day until you reach 30 drops 2 times a day. Start the Japanese Knotweed at ¼ tsp 3 times a day and in two weeks increase to ½ tsp 3 times a day.
Why Are Antibiotics The First Line Of Treatment For Lyme Disease
The use of antibiotics is critical for treating Lyme disease. Without antibiotic treatment, the Lyme disease causing bacteria can evade the host immune system, disseminate through the blood stream, and persist in the body. Antibiotics go into the bacteria preferentially and either stop the multiplication of the bacteria or disrupt the cell wall of the bacteria and kill the bacteria . By stopping the growth or killing the bacteria the human host immune response is given a leg up to eradicate the residual infection. Without antibiotics, the infection in Lyme disease can evade the host immune system and more readily persist.
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Antibiotic Treatment For Early
The first line of treatment for early Lyme disease is antibiotics. The most commonly prescribed antibiotics include:
- Cefuroxime axetil
These antibiotics are most often administered orally, though intravenous administration is necessary for some patients. Programs are typically 2 weeks long but can be as long as 4 or more weeks.
The Centers for Disease Control and Prevention and the Infectious Diseases Society of America maintain that most cases of Lyme disease clear up quickly from a short course of antibiotics. However, as you will see later in this article, there is much evidence showing that Lyme that is not detected early can actually be very difficult to treat and that even early treatment can be unsuccessful. The presence of coinfections can also complicate the treatment process, again emphasizing the need for comprehensive testing at a specialty lab.
Finally, as acknowledged by the CDC, some Lyme patients experience ongoing or recurrent symptoms despite having received treatment for Lyme. These patients are said to have Post-Treatment Lyme Disease Syndrome . Is this caused by untreated coinfections, persistence of Bb , permanent damage, or an as-yet unidentified immune system problem? The jury is still out, but all may be possible.
If Bitten By A Tick Should I Consider Immediate Antibiotics To Prevent Lyme Disease
ILADS recommends that prophylaxis be discussed with all who have had a blacklegged tick bite.An appropriate course of antibiotics has been shown to prevent the onset of infection.
When the decision is made to use antibiotic prophylaxis, ILADS recommends 20 days of doxycycline . The decision to treat a blacklegged tick bite with antibiotics often depends on where in the country the bite occurred, whether there was evidence that the tick had begun feeding, and the age of the person who was bitten. Based on the available evidence, and provided that it is safe to do so, ILADS recommends a 20-day course of doxycycline.
Patients should also know that although doxycycline can prevent cases of Lyme disease, ticks in some areas carry multiple pathogens, some of which, including Babesia, Powassan virus, and Bartonella, are not responsive to doxycycline. This means a person could contract a tick-borne illness despite receiving antibiotic prophylaxis for their known tick bite.
ILADS recommends against single-dose doxycycline. Some doctors prescribe a single 200 mg dose of doxycycline for a known bite. However, as discussed in detail in the guidelines, this practice is based on a flawed study that has never been replicated. Read more in the ILADS treatment guidelines.
The bottom line: If you have been bitten by a blacklegged tick, you should discuss immediate antibiotic treatment with your provider as a possible course of action.
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Free Sale A Number Of Drugs
The fraudulent websites allegedly offers for sale a number of drugs for the experimental and unapproved treatment or prevention of COVID-19. Instead, the domains were allegedly used to collect the personal information of individuals visiting the sites in order to use the information for nefarious purposes, including fraud, phishing attacks, and/or deployment of malware. Individuals visiting the sites will now see a message that the site has been seized by the federal government and be redirected to another site for additional information. These are the 12th and 13th COVID fraud related domain name seized by the Maryland U.S. Attorneys Office and HSI.Ivermectin is a Food and Drug Administration -approved antiparasitic drug that is used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 It is also being evaluated for its potential to reduce the rate of malaria transmission by killing mosquitoes that feed on treated humans and livestock.2 For these indications, ivermectin has been widely used and is generally well tolerated.1,3 Ivermectin is not approved by the FDA for the treatment of any viral infection.