Antimicrobials That Kill Growing Phase Cysts
Intracellular and Extracellular
Note: I work with the following agents as anti-cyst agents based on the mechanism by which these antibiotics work and some scientific experiments. For the Rifamycins, there are no laboratory experiments showing these agents work against cysts. Clinically, I see great benefit in using the Rifamycins as my anti-cyst agents so I list them here.
- Rifampin 300 mg 2 pills 1 time a day or 1 pill 2 times a day
- Rifabutin 150 mg 2 pills 1 time a day
- Tinidazole 500 mg 1 pill 2 or three times a day usually pulsed for four days on then three days off of each 7 days
- Metronidazole 500 mg 1 pill 2 or three times a day usually pulsed for four days on then three days off of each 7 days.
- Grapefruit seed extract 250 mg 1 pill 2 times a day. Note this is an herbal antibiotic that I find as effective as the prescription options in this list.
How Can Lyme Disease Be Prevented
Unfortunately, there is currently no vaccine for Lyme disease. But you can avoid Lyme disease by avoiding tick bites, checking for ticks, and removing ticks promptly, before they become lodged in the skin. Some tips:
Avoid tick playgrounds: Ticks like low-level shrubs and grasses, particularly at the edges of wooded areas. If youre hiking, try to stay in the center of the trail and avoid bushwhacking. Walk on cleared paths or pavement through wooded areas and fields when possible.
Dress appropriately: Long pants with legs tucked into socks and closed-toed shoes will help keep ticks away from skin. Light-colored clothing helps make ticks visible.
Insect repellant: Products that contain DEET repel ticks but do not kill them and are not 100 percent effective. Use a brand of insect repellent that is designated as child-safe if your child is 1 year or older. For infants, check with your pediatrician about what brands are safe to use. You can also treat clothing with a product that contains permethrin, which is known to kill ticks on contact.
Shower after outdoor activities are done for the day. It may take four to six hours for ticks to attach firmly to skin. Showering will help remove unattached ticks.
- all parts of the body that bend: behind the knees, between fingers and toes, underarms and groin
- other areas where ticks are commonly found: belly button, in and behind the ears, neck, hairline, and top of the head
- anywhere clothing presses on the skin
What You Need To Know About Lyme Disease
Lyme disease is an infection caused by the spiral-shaped bacteria Borrelia burgdorferi, which is most commonly transmitted by a tick bite.
There are over 300,000 estimated new cases of Lyme disease in the United States each year.
The symptoms of Lyme disease depend on the how long the infection has been present in the body. The first sign of Lyme disease is often an expanding round or oval red “bullseye” rash.
If left untreated, people may develop neurological symptoms and heart problems, and have an approximately 60 percent chance of developing Lyme arthritis.
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What Causes Lyme Disease
Lyme disease is caused by bacteria that is spread to humans by tick bites. The ticks that carry the spirochete are:
Black-legged deer tick
Western black-legged tick
Ticks prefer to live in wooded areas, low-growing grasslands, and yards. Not all ticks carry the Lyme disease bacteria. Depending on the location, anywhere from less than 1% to more than 50% of the ticks are infected with it.
While most tick bites are harmless, several species can cause life-threatening diseases. Tick-borne diseases include:
Rocky Mountain spotted fever
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Lyme Disease Rash Photos: Early
I recently got Lyme disease for the first time. Luckily, I was able to catch it early and, other than a few days of extreme fatigue, I am doing fine. Since my Lyme rash didnt look like a standard bulls-eye rash right away, I thought Id share some photos of my Lyme rash as well as photos of the standard bulls-eye rash and atypical rashes.
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Signs And Symptoms Of Lyme Disease
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Lyme disease is an underreported, under-researched, and often debilitating disease transmitted by spirochete bacteria. The spiral-shaped bacteria, Borrelia burgdorferi, are transmitted by blacklegged deer ticks. Lymes wide range of symptoms mimic those of many other ailments, making it difficult to diagnose .
The blacklegged ticks can also transmit other disease-causing bacteria, viruses, and parasites. These are known as coinfections . These ticks that transmit Lyme are increasing their geographical spread. As of 2016, they were found in about half the counties in 43 of 50 states in the United States .
Lyme is the fifth most reported of notifiable diseases in the United States, with an estimated 329,000 new cases found annually . Some studies estimate that there are as many as 1 million cases of Lyme in the United States every year .
Most people with Lyme who are treated right away with three weeks of antibiotics have a good prognosis.
But if youre not treated for weeks, months, or even years after infection, Lyme becomes more difficult to treat. Within days of the bite, the bacteria can move to your central nervous system, muscles and joints, eyes, and heart .
Here is a list of 13 common signs and symptoms of Lyme disease.
What Are The Second Stage Signs And Symptoms Of Lyme Disease
The symptoms of second stage, early disseminated, Lyme disease can be difficult to attribute. Symptoms include severe fatigue, fever, pain, intermittent weakness and achiness of the muscles and joints, numbness in arms and legs, vision changes, and cognitive dysfunction such as short-term memory difficulties and problems multitasking. These symptoms are not specific for Lyme disease and can make the diagnosis of second stage Lyme disease very challenging.
More recognizable Lyme disease nervous system manifestations include facial paralysis , or meningitis with severe headache and stiff neck. Notable cardiac manifestations include passing out or feeling faint from an abnormally slow heart rate, irregular heart palpitations, or unexplained difficulty tolerating exercise. Meningitis and carditis are both potentially serious Lyme disease conditions and warrant immediate medical attention.
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Bulls Eye Rash: A Lyme Disease Symptom Breakdown
There are many Lyme Disease symptoms to read about and breakdown. Today we breakdown a common symptom, bulls eye rash. Read more below
Bites and stings produce different symptoms, especially in the area around the spot where the insect made contact. Knowing the difference is essential to see if you should seek treatment. Here is a brief breakdown of common bites and stings:
- Mosquito bites leave round puffy bumps that can turn red and itch
- Fire ant stings leave red spots with small blisters in the center
- Flea bites are tiny red, itchy bumps
- Chigger bites can be welts, pimples, hives, or blisters that are itchy and painful
- Dangerous spiders leave two puncture marks side by side that produces a raised papule or blister some appear with a red rash and white center
- Bee stings leave white marks at the site of the sting with redness, swelling, and itchiness
- Wasp stings leave raised welts, redness, itchiness, and burning
Another common insect bite is from a deer tick, which occurs hundreds of thousands of times every year. There are significant differences between a deer tick and all other insects in how they bite and the after-effects.
What Specialists Treat Lyme Disease
A primary-care provider such as a family practitioner, internist, or childs pediatrician may initially diagnose Lyme disease. In areas where Lyme disease is common, these physicians often treat the illness, as well. However, you may be referred to a specialist for treatment. Rheumatologists specialize in diseases that affect the joints and muscles, including infectious diseases such as Lyme disease. You may also see a neurologist if you experience nerve problems or an infectious disease specialist who can help treat Lyme disease in the later stages.
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Identify The Tick You Were Bitten By
Its important to identify the tick because different kinds of ticks can carry different bacteria, viruses, protozoa and parasites.
There are two families of ticks found in the United States: Ixodidae and Argasidae . Of the 700 species of hard ticks and 200 species of soft ticks found throughout the world, only a few are known to bite and transmit disease to humans. Knowing the type of tick will help you be aware of what possible symptoms to watch for.
Lyme Disease Pictures & Tick Photos
The Lyme Disease Association offers this page to provide the general public and professionals with an array of tick images, rash images, and disease organisms to help in the determination of what is Lyme disease and what are other tick-borne diseases.
Many professionals have provided pictures to the Lyme Disease Association that show what some of the rash signs look like, tick images of various ticks that transmit a number of tick-borne diseases in the US, and infectious organisms seen under the microscope that are transmitted by ticks in the US.
This category of medical photos includes pictures of Lyme disease related rashes, ticks and organisms under the microscope.
There are 3 photo albums below: Lyme disease rashes, ticks and under the scope . To view each album click on pictures below.
The images are intended for education purposes only, and a medical professional should be consulted to determine if someone has a tick-borne disease. The LDA does maintain an online referral where someone can search for a Lyme disease doctor.
Latin Name : Diseases they can transmit
Ixodes scapularis :Lyme , Borrelia miyamotoi, babesiosis, anaplasmosis, Powassan encephalitis, tick paralysis, bartonellosis, ehrlichiosis .Ixodes scapularis have been shown to carry Ehrlichiosis , but to date, transmission is still in question
Amblyomma americanum : Human monocytic ehrlichiosis, STARI, tularemia, tick paralysis, Rocky Mountain spotted fever
Topics of Guest Blogs:
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Tetracycline Plus Macrolide Plus Grapefruit Seed Extract Plus Japanese Knotweed
- doxycycline 100 mg 2 pills 2 times a day
- clarithromycin 500 mg 1 pill 2 times a day
- grapefruit seed extract 250 mg 1 pill 2 times a day.
- Japanese knotweed½ tsp 3 times a day
- Tetracyclines and macrolides both block protein production by binding to the protein production apparatus in germs called ribosomes. But they each bind to a different part of the ribosome improving the blockade of protein production.
- Japanese knotweed is added here to treat persister Lyme. It also may treat growing Lyme and can lower inflammation cytokines.
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Symptoms Of Post Treatment Lyme Disease
- Include severe fatigue, musculoskeletal pain, & cognitive problems
- Can significantly impact patients health and quality of life
- Can be debilitating and prolonged
Our research indicates the chronic symptom burden related to PTLD is significant. Although often invisible to others, the negative impact on quality of life and daily functioning is substantial for PTLD sufferers.
The chronic symptom burden related to Lyme disease is considerable, as shown on the left side of the graph above, and statistically significantly greater than the aches and pains of daily living experienced by the control group, on the right.
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When To See Your Gp
You should contact your GP or dial NHS 111 promptly if you feel unwell with any of the symptoms described above after being bitten by a tick or after spending time in areas where ticks may live.
Take this leaflet with you if you are unsure what to say and remember to let your GP know if youve recently had a tick bite or spent time in areas where ticks may live.
Diagnosing Lyme disease can be difficult as many of the symptoms are similar to other conditions. A spreading erythema migrans rash appearing some days after a known tick bite is characteristic and should be treated with antibiotics.
If you dont have this rash but do have other symptoms of Lyme disease, blood tests can be carried out that look for antibodies against the borrelia bacteria.
Blood tests can be negative in the early stages of the infection as the antibodies take some time to reach levels that can be detected.
You may need to be re-tested if Lyme disease is still suspected 4 to 6 weeks after a first negative test result.
If you have long-lasting symptoms, you may be referred to a specialist in microbiology, infectious diseases, rheumatology, or neurology as appropriate for further investigation and management.
Stage : Early Localized Disease
Symptoms of Lyme disease usually start 1 to 2 weeks after the tick bite. One of the earliest signs of the disease is a bulls-eye rash.
The rash occurs at the site of the tick bite, usually, but not always, as a central red spot surrounded by a clear spot with an area of redness at the edge. It may be warm to the touch, but it isnt painful and doesnt itch. This rash will gradually fade in most people.
The formal name for this rash is erythema migrans. Erythema migrans is said to be characteristic of Lyme disease. However, many people dont have this symptom.
Some people have a rash thats solid red, while people with dark complexions may have a rash that resembles a bruise.
The rash can occur with or without systemic viral or flu-like symptoms.
Other symptoms commonly seen in this stage of Lyme disease include:
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Outlook For Early Disseminated Lyme Disease
If you receive a diagnosis and treatment with antibiotics at this stage, you can expect to be cured of Lyme disease. Without treatment, complications can occur. Treatments are available for the complications.
In rare cases, you may experience a continuation of Lyme disease symptoms after antibiotic treatment. This is called post-treatment Lyme disease syndrome .
Some people who were treated for Lyme disease report muscle and joint pain, cognitive difficulties, sleep issues, or fatigue after their treatments were finished.
The cause of this is unknown. However, researchers believe it may be due to an autoimmune response in which your immune system attacks healthy tissues. It may also be linked to an ongoing infection with the bacteria that causes Lyme disease.
The practices below can reduce your likelihood of contracting Lyme disease and having it progress to the early disseminated stage.
How To Avoid Contracting Lyme Disease
- Use insect repellant on your clothing and all exposed skin when walking in wooded or grassy areas where ticks thrive.
- Treat clothing and footwear with permethrin , an insect repellant that remains active through several washings.
- Walk in the center of trails to avoid high grass when hiking.
- After walking or hiking, change your clothes and perform a thorough check for ticks, focusing on the groin, scalp, and armpits.
- Check your pets for ticks.
Contact a doctor if a tick bites you. You should be observed for 30 days for signs of Lyme disease.
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What Are Lyme Disease Causes And Risk Factors
B. burgdorferi bacteria cause Lyme disease. The bacteria have a complex life cycle, spending part of their life in the deer tick and part in some mammals such as mice and deer.
Humans are not a part of the bacteriums life cycle but can become infected when bitten by the tick. Lyme disease is not contagious and cannot be passed from person to person.
While dogs and cats can get Lyme disease, there are no reported cases of these animals spreading the disease to their owners. However, dogs and cats can bring the infected ticks into the home, which is one reason why tick protection for pets is important. Talk to a veterinarian about the right type of tick control for any pets.
Risk factors for getting Lyme disease include the following:
- Living in the northeastern or Midwestern U.S. states where the disease is most prevalent
- Being outdoors in the woods or areas that have tall grass, shrubs, or brush
- Fishing, camping, hunting, yard work, hiking, and other outdoor activities in tick-infested areas
- Having bare, unprotected skin when outdoors in high-risk areas
- Pets who are not protected against ticks may bring them indoors.
- Not removing attached ticks promptly
- Swollen lymph nodes
- General feeling of being unwell
The initial infection can occur with minimal or no signs or symptoms. But many people experience a flu-like primary illness or a characteristic rash several days to a few weeks following a tick bite. This rash may feel warm to the touch but is rarely itchy or painful.
What Should I Do If I Find A Tick On My Child
Don’t panic. First Lyme disease is spread by the black-legged tick, not by the larger and more-common dog tick. The risk of developing Lyme disease after a black-legged tick bite is low, especially if the tick has been attached for a short time.
If you find a tick on your child, remove it using a fine-tipped pair of tweezers. Grasp the body of the tick and pull in an upward motion until the tick comes out. Do not squeeze or twist the ticks body. Take note of the ticks size and color, and how long you think it has been attached to your child.
If your child has been bitten by a black-legged tick that has been attached for more than 24 hours and you are in a Lyme disease endemic area, consult with your pediatrician. In some cases, your child may be prescribed antibiotics to prevent Lyme disease from developing.
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