Synovial Fluid Pcr For B Burgdorferi
Although reported in a few patients, it is exceedingly difficult to culture B. burgdorferi from synovial fluid in patients with Lyme arthritis. This is presumably due to the fact that joint fluid, with its many inflammatory mediators, is an extremely hostile environment. In spiked cultures, adding small amounts of joint fluid results in rapid killing of spirochetes. In contrast, polymerase chain reaction testing of synovial fluid for B. burgdorferi DNA often yields positive results before antibiotic therapy ,, and usually becomes negative following antibiotic treatment. However, spirochetal DNA may persist after spirochetal killing, which limits its use as a test for active infection. Moreover, PCR testing has not been standardized for routine clinical use. Therefore, in most cases, the appropriate clinical picture and a positive serologic result are sufficient for diagnosis of Lyme arthritis, and PCR testing serves as an optional test to further support the diagnosis.
Cytokine Inflammation In Lyme Disease Pain
It is well known that Lyme disease triggers white blood cells to make excess inflammation chemicals called cytokines. These cytokines cause pain. For a detailed description of this and a review of treatments see Control Cytokines: A Guide to Fix Lyme Symptoms & The Immune System.
Lyme disease Pain Strategy
So one strategy to lower pain in Lyme disease is to take herbs and supplements that may support lowering cytokines. These include curcumin and liposomal glutathione. Low dose naltrexone , a prescription medicine, can also lower cytokines.
What Exactly Is Lyme Disease
Lyme disease is transmitted from certain types of ticks to humans through bite. This specific kind of infection that results in Lyme disease is spirochete or corkscrew-shaped bacteria known as Borrelia burgdorferi. It is spread via ticks that have fed on deer in specific parts of the U.S. It can have an effect on any organ inside the body, including the heart, the brain and nervous system, and the muscles and joints. It is important to check yourself for ticks frequently if you are in a tick-infested area. The longer a tick is attached, the higher your chances of contracting Lyme.
Lyme is often referred to as The Great Imitator, because its symptoms copy those of many other diseases. Because of this mimicking aspect of Lyme, many people that contract the disease are misdiagnosed. Some common misdiagnoses include: chronic fatigue, fibromyalgia, multiple sclerosis, depression, and others.
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Testing And Antibiotic Treatment
Diagnosis of LD usually is confirmed by serologic testing. Once LD is diagnosed, treatment of the infection requires antibiotics. There is some controversy surrounding diagnostic testing and antibiotic therapy. Ideally, antibiotic management of LD should be supervised by a physician with expertise or specialization in LD. Antibiotics commonly used for oral treatment include doxycycline , amoxicillin, and cefuroxime axetil.17 Patients with certain neurologic or cardiac forms of illness may require intravenous treatment with drugs such as ceftriaxone or penicillin.17 . If a specialist is not available and the treating pain clinician tests and treats, we recommend you consult Clinical Practice Guidelines or another up-to-date manual.17
Neck Pain From Lyme Disease
Lyme disease is commonly associated with tick bites and a big circular rash. However, a tick bite does not hurt and many people do not recall being bit or seeing the rash. Further complicating matters, Lyme disease symptoms may start out minor and not become problematic for months or longer.
Lyme disease causes neck pain in more than 30% of cases. Watch:Neck Pain Causes Video
Media reports rarely focus on neck pain with Lyme disease, but some estimates note that it occurs in more than 30% of the cases and is typically one of the earlier symptoms.1 Recognizing Lyme disease early and seeking treatment can make a big difference in the outcome.
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Managing Chronic Pain For Lyme Disease Patients
Lyme disease is a debilitating condition that can, unfortunately, produce symptoms even after the illness has been treated. As we had mentioned in our blog overview, a rash in the form of a bulls-eye pattern is generally the first indication of an infected tick bite . Following the rash, flu-like symptoms typically develop such as fatigue, fever, chills, body aches, and headache.
If the illness is left untreated, chronic joint pain and neurological problems like meningitis, Bells palsy, numbness or weakness in the limbs, and impaired muscle movement may also occur. In these cases, a pain management program is often beneficial to mitigate symptoms.
At Tulsa Pain, managing chronic pain in Lyme disease patients often requires a multidisciplinary treatment approach. Pain medication, although effective, is not the only method for controlling pain and discomfort, which is why its imperative patients see a pain specialist for care. Patients should see their primary physician for antibiotics to control of their infection and a pain management specialist at Tulsa Pain to establish a positive patient experience and continuum of care.
Treatment for chronic pain in Lyme disease patients may include a combination of the following:
- Electrical stimulation
Be Mindful Of What You Eat
Processed foods, sugar, gluten, and dairy tend to be inflammatory for most people, and they neglect to deliver the vital nutrients your body needs to keep neuropathy at bay and manage pain. Not only are these types of foods an insufficient source of nourishment, but many are also filled with artificial ingredients like dyes, preservatives, and other additives that contribute to inflammation and increase pain. Additionally, foods and beverages that contain gluten, salt, and alcohol can exacerbate symptoms try to steer clear of them as best you can.
Right about now, you might be asking, You just named all the good stuff. So, what can I eat? Plenty, I promise!
Start by replacing pre-packaged, refined foods with nutrient-dense vegetables, low-sugar fruits, lean meats, and healthy fats, especially those high in inflammation-fighting omega-3s. A good rule of thumb to follow is to fill your plate with at least 50% vegetables.
With this strategy, youll be well on your way to minimizing your intake of problematic foods. If youre unsure of whether a particular food is causing a flare-up, you might choose to begin an elimination diet and keep a food journal so you can more accurately identify triggers that could be contributing to the severity of the issue.
What Causes Brain Fog
The Pathogens Themselves
|Lyme is also capable of moving beyond the blood brain barrier which is supposed to protect the brain from pathogens such as Lyme. This is why its very important to have a treatment protocol that consists of some type of antimicrobial that can cross the blood brain barrier as well.Toxins – The Lyme bacteria releases two types of toxins in the body – exotoxins, which are toxins they release all the time as waste material, and endotoxins, which are toxins they release when their cell walls are lysed from either the immune system or some type of antibiotic or antimicrobial.
Muscle Spasm Pain In Lyme Disease
Due to inflammation or nerve injury, many with Lyme have pain due to muscle spasm. In addition to strategies to lower cytokines and to control nerve pain signals, muscle relaxers can help with this situation.
Lyme Disease Pain Strategy
Magnesium is a useful supplement that supports muscle relaxation. The salt forms of magnesium that are most helpful for this are Magnesium Malate and Magnesium Citrate. Prescription muscle relaxers are also helpful.
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What Are The Symptoms Of Lyme Disease
Symptoms of Lyme disease can be different from person to person.
Early signs and symptoms of Lyme disease usually start 3 to 30 days after you have been bitten by an infected blacklegged tick. Most people experience mild flu-like symptoms soon after being bitten, while a small number may have more serious symptoms, sometimes weeks after the bite.
Early signs and symptoms of Lyme disease may include:
- Rash, sometimes shaped like a bull’s eye )
- Muscle and joint aches
- Swollen lymph nodes
If left untreated, more severe symptoms may occur and can last from months to years. Severe symptoms may include:
- Severe headaches
- Facial paralysis
- Intermittent muscle, joint, tendon and bone aches
- Heart disorders , known as Lyme carditis
- Neurological disorders
- Arthritis with severe joint pain and swelling, particularly the knees and less commonly in other joints such as the ankle, elbow and wrists.
In rare cases, Lyme disease can lead to death usually because of complications involving infection of the heart.
Three Stages Of Active Infection
Infection following a tick bite causes 3 stages of disease . The early localized infection causes a rash called erythema migrans, commonly called a bulls-eye rash, which eventually resolves, even without antibiotic treatment. Although diagnostic following a tick bite, the rash only occurs in about half of LD cases. In the early stages of infection, the spirochete can spread to other tissues and organs , causing more severe symptoms.8 LD has a predilection to attack the facial nerve and cause Bells palsy.13-16 The disease also commonly affects the neck and cervical spine, causing pain, stiffness, headache, and possible radicular symptoms. Joint, muscle, and nerve pain begin to occur during active infection, with the knee being a favored site of joint pain.4-6
The late, disseminated stage of infection is characterized by neurologic manifestations and severe arthritic pain in joints.2-16 There may be shooting pains, myalgias, numbness or tingling in the hands or feet, insomnia, and problems with short-term memory. Tragically, the spirochete may have a predilection for the central nervous system .13-16 Once infected, CNS LD may cause a number of symptoms that may mimic other neurologic diseases, including multiple sclerosis, Parkinsons disease, and Alzheimers disease. Many physicians refer to CNS infection by LD as neuroborreliosis.6,10,13-16
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What Is Lyme Arthritis
Lyme arthritis occurs when Lyme disease bacteria enter joint tissue and cause inflammation. If left untreated, permanent damage to the joint can occur. Lyme arthritis accounts for approximately one out of every four Lyme disease cases reported to CDC. Because of reporting practices, this statistic may overstate the frequency of arthritis among patients seen in routine clinical practice.
Lyme The Nervous System And Neuropathy
Unfortunately, once the infection begins to spread throughout the body, many people will develop Lyme neuroborreliosis . This is neurological Lyme disease, which affects and inflames the central and peripheral nervous systems.
Research suggests the neurologic manifestations of Lyme disease may be present in approximately 15% of the patient population. However, the exact incidence of LNB isnt well known. A brief stint in an online Lyme patient forum will quickly reveal that most individuals report experiencing at least some amount of neurological involvement on a routine basis.
One debilitating symptom that may be present among those with LNB is peripheral neuropathy . This is a disease process that impacts the nerves located outside of the brain and spinal cord. Neuropathy occurs when there is damage or dysfunction of neurons in one or more nerves.
The damage results in interference among the neurons, and they begin to have difficulty communicating with each other and the brain.
To make matters worse, co-infections like Babesia and Bartonella can contribute to neuropathy as well, according to a study in the International Journal of General Medicine.
So how do you know if the symptoms youre facing are neuropathy, and what can you do to find some relief? Read on to learn about the symptoms, diagnosis, and ideas on how to manage the pain and discomfort associated with neuropathy more effectively.
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What Is Post Treatment Lyme Disease
Post Treatment Lyme Disease represents a research subset of patients who remain significantly ill 6 months or more following standard antibiotic therapy for Lyme disease. PTLD is characterized by a constellation of symptoms that includes severe fatigue, musculoskeletal pain, sleep disturbance, depression, and cognitive problems such as difficulty with short-term memory, speed of thinking, or multi-tasking. In the absence of a direct diagnostic biomarker blood test, PTLD has been difficult to define by physicians, and its existence has been controversial. However, our clinical research shows that meticulous patient evaluation when used alongside appropriate diagnostic testing can reliably identify patients with a history of previously treated Lyme disease who display the typical symptom patterns of PTLD.
Lyme Disease And Joint Pain: Its Complicated
For starters, Lyme is complicated and every patient responds to the disease differently.
Approximately 30,000 new cases of Lyme are diagnosed each year, according to the CDC, and just over one-third of them develop arthritis as a symptom. The most common symptoms beyond the bullseye rash are chills, fatigue, headache/neck stiffness, fever. Painful and swollen jointsespecially in large joints such as the kneeare often considered a late-stage symptom of Lyme, but can appear even days after the tick bite.1-3 Some individuals may find out they have Lyme as a result of chronic joint painwithout ever knowing they had a tick bite.
Ticks rarely carry just one strain of bacteria. They usually deliver several different species of bacteria and parasites in one bite these are called co-infections. Co-infections are one reason Lyme disease diagnosis and treatment can be so complex and difficult.
To investigate why joint pain is a common symptom of Lyme disease, I spoke to Thalia Farshchian, ND, a naturopathic doctor practicing at Medical Options for Wellness, a clinic in Foster City, California. She specializes in treating patients affected by chronic and complex diseases, including Lyme disease.
It is estimated that about 70% of individuals presenting with bullseye rash do not recall a tick bite,” she said. “It is important to note that the absence of a rash does not rule out Lyme Disease as diagnosis, but may be supportive of the diagnosis.”
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Banderol And Cats Claw
“These two herbs are commonly dosed together because they work synergistically with clinically proven action against Borrelia species,” Greenspan says. “The goals with any treatment with Lyme disease spirochetes, whether chronic or acute, is to have a combination of herbs to be effective with the shape-shifting behavior of this microbe.”
Dos And Donts Of Getting Help
If you think you may have this syndrome, experts suggest these tips:
Donât assume. Tell your doctor your symptoms, and let her check you.
Donât rush to a specialist. For an accurate diagnosis, start with a primary care doctor, says Eugene Shapiro, MD. He’s a professor of pediatrics, epidemiology, and investigative medicine at Yale School of Public Health.
Do take your antibiotic as prescribed. Even if you feel better, continue the course. Itâs 4 weeks of medications at most. Some experts believe stopping the drugs before your prescription ends may cause symptoms to linger.
Do find experts who can help your symptoms. Ask your doctor if it would be worth your while to visit naturopaths, traditional Chinese medicine doctors, psychologists, or other experts. Many medical centers have complementary and alternative medicine experts on site.
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Managing Lyme Arthritis Pain: Can Herbs Help
Stephen Harrod Buhner is a well-known herbalist and author who specializes in the treatment of Lyme disease and co-infections. His book, Healing Lyme, Natural Healing of Lyme Borreliosis and the Coinfections Chlamydia and Spotted Fever Rickettsioses, is based on extensive research on Lyme disease and was the first book I bought after my Lyme diagnosis.4 It offers an exhaustive description of what occurs during Lyme infection, as well as a detailed herbal protocol that Ive been following for the past 3 years.
Buhner writes that Lyme joint pain is caused by the way Borrelia burgdorferi interacts with joint spaces in the body. According to Buhners book, The most important thing to understand about Lyme disease is that the bacteria have an affinity for collagenous tissue. This is at the root of every symptom they cause… Wherever feed on those tissues is where the symptoms occur.
Joints are largely composed of collagen both cartilage and synovial fluid are collagenous structures. Lyme bacteria break down and eat collagen wherever they lodge. As you can imagine, this leads to inflammation and pain.
Lyme can plant itself into any collagenous tissue in the body meaning it can infect any joint space. It can also choose the myelin sheaths around nerve tissue in the brain or spinal cord, also made of collagen. This results in neurological symptoms, and is another reason Lyme patients symptoms and pain are so different.
What Is Lyme Disease
Lyme disease is a bacterial infection caused by the bacteria Borrelia burgdorferi, affecting an estimated 329,000 individuals in the United States each year. It is spread through the bites of infected blacklegged ticks, commonly known as deer ticks.
Lyme disease can cause fatigue, fever, and joint and muscle pain. When treated with antibiotics in the early stages, most people make a quick and complete recovery. If left untreated, Lyme disease can lead to serious joint and nervous system complications.
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Be Ready For Trial And Error
Lyme-related joint pain takes time to both diagnose and treat. In the meantime, there are many things you can do to decrease inflammation and pain. As every Lyme patient is different, try not to get too frustrated if what works for someone else doesnt work for you. Be patient as you experiment with diet, herbs, exercise, alignment, and releasing tight fascia. You will find tools that help you. Reach out and surround yourself with people who understand you and are on your side. We are all healing together.
Natural Remedies For Lyme Disease
Lyme disease is a bacterial infection caused by the bacterium Borrelia burgdorferi. It is spread through the bite of infected ticks.
Ticks are very small, and their biteswhich can occur anywhere on the bodyare usually painless, so you may not immediately be aware that you have been bitten. In most cases, the tick must be attached to the body for 24 hours before Lyme disease is transmitted.
The signs and symptoms of Lyme disease usually start within three to 30 days after youve been bitten by an infected tick. Many people experience flu-like symptoms after being bitten, while more serious symptoms show up weeks after the bite. Early signs and symptoms of Lyme disease include:
- Swollen lymph nodes
If left untreated, symptoms can worsen to include Bells palsy , severe headaches, muscle, joint, and tendon pain, cardiac problems, and neurological disorders.
Most cases of Lyme disease can be managed and treated with two to three weeks of antibiotics. Depending on the severity of your symptoms and how long after the bite you were diagnosed, you may need a longer course of antibiotics to clear up the infection. Many people turn to natural remedies to help treat Lyme disease.
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